Stereocontrolled synthesis of the aconitine D ring from d-glucose

Ian A. Pocock, Julien Doulcet, Craig R. Rice, Joseph B. Sweeney, Duncan M. Gill

Research output: Contribution to journalArticlepeer-review


The synthesis of a fully oxygenated aconitine D ring precursor from (d)-(+)-glucose is described. The route features a highly diastereoselective alkynyl Grignard ketone addition and a base-mediated enelactone to 1,3-diketone rearrangement.

Original languageEnglish
Pages (from-to)4347-4352
Number of pages6
JournalOrganic and Biomolecular Chemistry
Issue number21
Early online date3 May 2024
Publication statusPublished - 7 Jun 2024

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