Stereoselective synthesis of a dialkylhydantoin featuring an asymmetric Strecker reaction on an acyclic dialkyl ketone

Neil Barnwell, Andrew Watts, Lindsay Purdie, Duncan M. Gill

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A diastereoselective Strecker reaction using (R)-(-)-phenylglycinol forms the basis of a concise scalemic route to dialkylhydantoin 1. The phenylglycinol functionality was exploited in the manipulation of the aminonitrile Strecker product through to the dialkylhydantoin via a short, efficient sequence involving crystalline intermediates.

Original languageEnglish
Pages (from-to)1951-1953
Number of pages3
JournalTetrahedron Letters
Volume53
Issue number15
Early online date10 Feb 2012
DOIs
Publication statusPublished - 11 Apr 2012
Externally publishedYes

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