Stereoselective synthesis of a dialkylhydantoin featuring an asymmetric Strecker reaction on an acyclic dialkyl ketone

Neil Barnwell, Andrew Watts, Lindsay Purdie, Duncan M. Gill

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A diastereoselective Strecker reaction using (R)-(-)-phenylglycinol forms the basis of a concise scalemic route to dialkylhydantoin 1. The phenylglycinol functionality was exploited in the manipulation of the aminonitrile Strecker product through to the dialkylhydantoin via a short, efficient sequence involving crystalline intermediates.

LanguageEnglish
Pages1951-1953
Number of pages3
JournalTetrahedron Letters
Volume53
Issue number15
Early online date10 Feb 2012
DOIs
Publication statusPublished - 11 Apr 2012
Externally publishedYes

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Ketones
Crystalline materials
N-phenylethanolamine

Cite this

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Stereoselective synthesis of a dialkylhydantoin featuring an asymmetric Strecker reaction on an acyclic dialkyl ketone. / Barnwell, Neil; Watts, Andrew; Purdie, Lindsay; Gill, Duncan M.

In: Tetrahedron Letters, Vol. 53, No. 15, 11.04.2012, p. 1951-1953.

Research output: Contribution to journalArticle

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