Strategy for Imidazotetrazine Prodrugs with Anticancer Activity Independent of MGMT and MMR

Keyphrases

• Acid-stable 50%
• Activity-dependent 100%
• Alkyl 50%
• Anticancer Activity 100%
• Antitumor Activity 50%
• Aqueous System 50%
• Aziridinium Ion 50%
• Diazonium Ions 50%
• DNA Alkylator 50%
• DNA Mismatch Repair 50%
• Imidazotetrazines 100%
• O6-methylguanine-DNA Methyltransferase 50%
• Prodrug 100%
• Temozolomide 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Antitumor Activity 50%
• Aziridine 50%
• Methylated DNA Protein Cysteine Methyltransferase 50%
• Prodrug 100%
• Temozolomide 50%