Keratosis palmoplantaris striata brunauer-fuhs-siemens-klinische, lipidbiochemische und molekularbiologische untersuchungen

Translated title of the contribution: Striate palmoplantar keratoderma. Clinical, lipidbiochemical and molecular investigations

W. Kuster, H. C. Hennies, A. Reis

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The plaque-like or striate form of palmoplantar keratoderma, type Brunauer-Fuhs-Siemens, should be distinguished from the more common diffuse and punctate types of palmoplantar keratoderma. A family with typical clinical features of this autosomal dominantly inherited keratinisation disorder is presented. Treatment with systemic retinoids is effective. Lipidbiochemical analysis of plantar stratum corneum showed reduced amounts of total ceramides and an increase of free fatty acids. These results are possibly a secondary effect of the altered keratinisation. Linkage analysis could exclude both type I and type II keratin genes as candidate genes for this genodermatosis.

Original languageGerman
Pages (from-to)263-268
Number of pages6
JournalH+G Zeitschrift fur Hautkrankheiten
Volume70
Issue number4
Publication statusPublished - 1 Jan 1995
Externally publishedYes

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Palmoplantar Keratoderma
Keratoderma, Palmoplantar, Diffuse
Type I Keratin
Type II Keratin
Ceramides
Retinoids
Nonesterified Fatty Acids
Cornea
Genes

Cite this

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title = "Keratosis palmoplantaris striata brunauer-fuhs-siemens-klinische, lipidbiochemische und molekularbiologische untersuchungen",
abstract = "The plaque-like or striate form of palmoplantar keratoderma, type Brunauer-Fuhs-Siemens, should be distinguished from the more common diffuse and punctate types of palmoplantar keratoderma. A family with typical clinical features of this autosomal dominantly inherited keratinisation disorder is presented. Treatment with systemic retinoids is effective. Lipidbiochemical analysis of plantar stratum corneum showed reduced amounts of total ceramides and an increase of free fatty acids. These results are possibly a secondary effect of the altered keratinisation. Linkage analysis could exclude both type I and type II keratin genes as candidate genes for this genodermatosis.",
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Keratosis palmoplantaris striata brunauer-fuhs-siemens-klinische, lipidbiochemische und molekularbiologische untersuchungen. / Kuster, W.; Hennies, H. C.; Reis, A.

In: H+G Zeitschrift fur Hautkrankheiten, Vol. 70, No. 4, 01.01.1995, p. 263-268.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Keratosis palmoplantaris striata brunauer-fuhs-siemens-klinische, lipidbiochemische und molekularbiologische untersuchungen

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AU - Hennies, H. C.

AU - Reis, A.

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AB - The plaque-like or striate form of palmoplantar keratoderma, type Brunauer-Fuhs-Siemens, should be distinguished from the more common diffuse and punctate types of palmoplantar keratoderma. A family with typical clinical features of this autosomal dominantly inherited keratinisation disorder is presented. Treatment with systemic retinoids is effective. Lipidbiochemical analysis of plantar stratum corneum showed reduced amounts of total ceramides and an increase of free fatty acids. These results are possibly a secondary effect of the altered keratinisation. Linkage analysis could exclude both type I and type II keratin genes as candidate genes for this genodermatosis.

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KW - molecular biology

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