Structural biology and biochemistry of cytochrome P450 systems in Mycobacterium tuberculosis

Kirsty J. McLean, Andrew W. Munro

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

The global spread of tuberculosis (TB) has been fuelled by the development of strains of the causative bacterium (Mycobacterium tuberculosis, Mtb) that are resistant to all the leading drugs. New TB therapies are desperately needed, but recent genome sequence, genetic and protein characterization studies have helped identify novel Mtb drug targets and key biochemical pathways for strategic intervention. Of particular interest are the multiple cytochrome P450 (P450) enzymes encoded in the Mtb genome. Structural, biochemical and mechanistic studies on these systems have demonstrated their potential as antitubercular targets, as well as revealing novel aspects of P450 form and function.

Original languageEnglish
Pages (from-to)427-446
Number of pages20
JournalDrug Metabolism Reviews
Volume40
Issue number3
DOIs
Publication statusPublished - 1 Jul 2008
Externally publishedYes

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