Structuring of Hydrogels across Multiple Length Scales for Biomedical Applications

Megan E. Cooke, Simon W. Jones, Britt ter Horst, Naiem Moiemen, Martyn Snow, Gurpreet Chouhan, Lisa J. Hill, Maryam Esmaeli, Richard J.A. Moakes, James Holton, Rajpal Nandra, Richard L. Williams, Alan M. Smith, Liam M. Grover

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The development of new materials for clinical use is limited by an onerous regulatory framework, which means that taking a completely new material into the clinic can make translation economically unfeasible. One way to get around this issue is to structure materials that are already approved by the regulator, such that they exhibit very distinct physical properties and can be used in a broader range of clinical applications. Here, the focus is on the structuring of soft materials at multiple length scales by modifying processing conditions. By applying shear to newly forming materials, it is possible to trigger molecular reorganization of polymer chains, such that they aggregate to form particles and ribbon-like structures. These structures then weakly interact at zero shear forming a solid-like material. The resulting self-healing network is of particular use for a range of different biomedical applications. How these materials are used to allow the delivery of therapeutic entities (cells and proteins) and as a support for additive layer manufacturing of larger-scale tissue constructs is discussed. This technology enables the development of a range of novel materials and structures for tissue augmentation and regeneration.

Original languageEnglish
Article number1705013
Number of pages15
JournalAdvanced Materials
Volume30
Issue number14
Early online date12 Feb 2018
DOIs
Publication statusPublished - 5 Apr 2018

Fingerprint

Hydrogels
Tissue
Polymers
Physical properties
Proteins
Processing

Cite this

Cooke, M. E., Jones, S. W., ter Horst, B., Moiemen, N., Snow, M., Chouhan, G., ... Grover, L. M. (2018). Structuring of Hydrogels across Multiple Length Scales for Biomedical Applications. Advanced Materials, 30(14), [1705013]. https://doi.org/10.1002/adma.201705013
Cooke, Megan E. ; Jones, Simon W. ; ter Horst, Britt ; Moiemen, Naiem ; Snow, Martyn ; Chouhan, Gurpreet ; Hill, Lisa J. ; Esmaeli, Maryam ; Moakes, Richard J.A. ; Holton, James ; Nandra, Rajpal ; Williams, Richard L. ; Smith, Alan M. ; Grover, Liam M. / Structuring of Hydrogels across Multiple Length Scales for Biomedical Applications. In: Advanced Materials. 2018 ; Vol. 30, No. 14.
@article{3ffee0c111fa4ba3af74ead8cd04bfc2,
title = "Structuring of Hydrogels across Multiple Length Scales for Biomedical Applications",
abstract = "The development of new materials for clinical use is limited by an onerous regulatory framework, which means that taking a completely new material into the clinic can make translation economically unfeasible. One way to get around this issue is to structure materials that are already approved by the regulator, such that they exhibit very distinct physical properties and can be used in a broader range of clinical applications. Here, the focus is on the structuring of soft materials at multiple length scales by modifying processing conditions. By applying shear to newly forming materials, it is possible to trigger molecular reorganization of polymer chains, such that they aggregate to form particles and ribbon-like structures. These structures then weakly interact at zero shear forming a solid-like material. The resulting self-healing network is of particular use for a range of different biomedical applications. How these materials are used to allow the delivery of therapeutic entities (cells and proteins) and as a support for additive layer manufacturing of larger-scale tissue constructs is discussed. This technology enables the development of a range of novel materials and structures for tissue augmentation and regeneration.",
keywords = "Biomaterials, Hydrogels, Regenerative medicine, Soft materials, Structuring",
author = "Cooke, {Megan E.} and Jones, {Simon W.} and {ter Horst}, Britt and Naiem Moiemen and Martyn Snow and Gurpreet Chouhan and Hill, {Lisa J.} and Maryam Esmaeli and Moakes, {Richard J.A.} and James Holton and Rajpal Nandra and Williams, {Richard L.} and Smith, {Alan M.} and Grover, {Liam M.}",
note = "This is the peer reviewed version of the following article: Cooke, M. E. et al (2018) Structuring of Hydrogels across Multiple Length Scales for Biomedical Applications. Advanced Materials 30 (4), which has been published in final form at https://doi.org/10.1002/adma.201705013. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.",
year = "2018",
month = "4",
day = "5",
doi = "10.1002/adma.201705013",
language = "English",
volume = "30",
journal = "Advanced Materials",
issn = "0935-9648",
publisher = "Wiley-VCH Verlag",
number = "14",

}

Cooke, ME, Jones, SW, ter Horst, B, Moiemen, N, Snow, M, Chouhan, G, Hill, LJ, Esmaeli, M, Moakes, RJA, Holton, J, Nandra, R, Williams, RL, Smith, AM & Grover, LM 2018, 'Structuring of Hydrogels across Multiple Length Scales for Biomedical Applications', Advanced Materials, vol. 30, no. 14, 1705013. https://doi.org/10.1002/adma.201705013

Structuring of Hydrogels across Multiple Length Scales for Biomedical Applications. / Cooke, Megan E.; Jones, Simon W.; ter Horst, Britt; Moiemen, Naiem; Snow, Martyn; Chouhan, Gurpreet; Hill, Lisa J.; Esmaeli, Maryam; Moakes, Richard J.A.; Holton, James; Nandra, Rajpal; Williams, Richard L.; Smith, Alan M.; Grover, Liam M.

In: Advanced Materials, Vol. 30, No. 14, 1705013, 05.04.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Structuring of Hydrogels across Multiple Length Scales for Biomedical Applications

AU - Cooke, Megan E.

AU - Jones, Simon W.

AU - ter Horst, Britt

AU - Moiemen, Naiem

AU - Snow, Martyn

AU - Chouhan, Gurpreet

AU - Hill, Lisa J.

AU - Esmaeli, Maryam

AU - Moakes, Richard J.A.

AU - Holton, James

AU - Nandra, Rajpal

AU - Williams, Richard L.

AU - Smith, Alan M.

AU - Grover, Liam M.

N1 - This is the peer reviewed version of the following article: Cooke, M. E. et al (2018) Structuring of Hydrogels across Multiple Length Scales for Biomedical Applications. Advanced Materials 30 (4), which has been published in final form at https://doi.org/10.1002/adma.201705013. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

PY - 2018/4/5

Y1 - 2018/4/5

N2 - The development of new materials for clinical use is limited by an onerous regulatory framework, which means that taking a completely new material into the clinic can make translation economically unfeasible. One way to get around this issue is to structure materials that are already approved by the regulator, such that they exhibit very distinct physical properties and can be used in a broader range of clinical applications. Here, the focus is on the structuring of soft materials at multiple length scales by modifying processing conditions. By applying shear to newly forming materials, it is possible to trigger molecular reorganization of polymer chains, such that they aggregate to form particles and ribbon-like structures. These structures then weakly interact at zero shear forming a solid-like material. The resulting self-healing network is of particular use for a range of different biomedical applications. How these materials are used to allow the delivery of therapeutic entities (cells and proteins) and as a support for additive layer manufacturing of larger-scale tissue constructs is discussed. This technology enables the development of a range of novel materials and structures for tissue augmentation and regeneration.

AB - The development of new materials for clinical use is limited by an onerous regulatory framework, which means that taking a completely new material into the clinic can make translation economically unfeasible. One way to get around this issue is to structure materials that are already approved by the regulator, such that they exhibit very distinct physical properties and can be used in a broader range of clinical applications. Here, the focus is on the structuring of soft materials at multiple length scales by modifying processing conditions. By applying shear to newly forming materials, it is possible to trigger molecular reorganization of polymer chains, such that they aggregate to form particles and ribbon-like structures. These structures then weakly interact at zero shear forming a solid-like material. The resulting self-healing network is of particular use for a range of different biomedical applications. How these materials are used to allow the delivery of therapeutic entities (cells and proteins) and as a support for additive layer manufacturing of larger-scale tissue constructs is discussed. This technology enables the development of a range of novel materials and structures for tissue augmentation and regeneration.

KW - Biomaterials

KW - Hydrogels

KW - Regenerative medicine

KW - Soft materials

KW - Structuring

UR - http://www.scopus.com/inward/record.url?scp=85041846509&partnerID=8YFLogxK

U2 - 10.1002/adma.201705013

DO - 10.1002/adma.201705013

M3 - Article

VL - 30

JO - Advanced Materials

JF - Advanced Materials

SN - 0935-9648

IS - 14

M1 - 1705013

ER -

Cooke ME, Jones SW, ter Horst B, Moiemen N, Snow M, Chouhan G et al. Structuring of Hydrogels across Multiple Length Scales for Biomedical Applications. Advanced Materials. 2018 Apr 5;30(14). 1705013. https://doi.org/10.1002/adma.201705013