Studies on the anti-inflammatory and related pharmacological properties of the aqueous extract of Bridelia ferruginea stem bark

Olumayokun A. Olajide, J. Modupe Makinde, David T. Okpako, S. Olubusayo Awe

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The anti-inflammatory profile of the aqueous extract of Bridelia ferruginea stem bark was investigated using both in vivo and in vitro models. The extract exhibited strong topical anti-inflammatory effect shown as inhibition of croton oil-induced ear oedema in mice, and reduced hind-paw swelling and growth retardation in the adjuvant-induced arthritis model in rats, following oral administration at 10, 20, 40 or 80 mg/kg. The extract (10-80 mg/kg, p.o.) caused an inhibition of increase in vascular permeability in both cyclophosphamide-induced haemorrhagic cystitis and acetic acid-induced vascular permeability in rats and mice, respectively. B. ferruginea produced stabilization of erythrocytes exposed to heat and stress-induced lysis. Antipyretic and analgesic properties of the extract were also observed. Copyright (C) 2000 Elsevier Science Ireland Ltd.

LanguageEnglish
Pages153-160
Number of pages8
JournalJournal of Ethnopharmacology
Volume71
Issue number1-2
DOIs
Publication statusPublished - 1 Jul 2000
Externally publishedYes

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Capillary Permeability
Anti-Inflammatory Agents
Croton Oil
Pharmacology
Antipyretics
Experimental Arthritis
Cystitis
Acetic Acid
Cyclophosphamide
Ear
Oral Administration
Analgesics
Edema
Hot Temperature
Erythrocytes
Growth
In Vitro Techniques

Cite this

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abstract = "The anti-inflammatory profile of the aqueous extract of Bridelia ferruginea stem bark was investigated using both in vivo and in vitro models. The extract exhibited strong topical anti-inflammatory effect shown as inhibition of croton oil-induced ear oedema in mice, and reduced hind-paw swelling and growth retardation in the adjuvant-induced arthritis model in rats, following oral administration at 10, 20, 40 or 80 mg/kg. The extract (10-80 mg/kg, p.o.) caused an inhibition of increase in vascular permeability in both cyclophosphamide-induced haemorrhagic cystitis and acetic acid-induced vascular permeability in rats and mice, respectively. B. ferruginea produced stabilization of erythrocytes exposed to heat and stress-induced lysis. Antipyretic and analgesic properties of the extract were also observed. Copyright (C) 2000 Elsevier Science Ireland Ltd.",
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Studies on the anti-inflammatory and related pharmacological properties of the aqueous extract of Bridelia ferruginea stem bark. / Olajide, Olumayokun A.; Makinde, J. Modupe; Okpako, David T.; Awe, S. Olubusayo.

In: Journal of Ethnopharmacology, Vol. 71, No. 1-2, 01.07.2000, p. 153-160.

Research output: Contribution to journalArticle

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