Studies on the anti-inflammatory, antipyretic and analgesic properties of Alstonia boonei stem bark

Olumayokun A. Olajide, S. Olubusayo Awe, J. Modupe Makinde, Ambrose I. Ekhelar, Akin Olusola, Olugbenga Morebise, David T. Okpako

Research output: Contribution to journalArticle

150 Citations (Scopus)

Abstract

The methanol extract of the stem bark of Alstonia boonei was investigated for anti-inflammatory property. The analgesic and antipyretic properties of the extract was also evaluated. The extract caused a significant (P<0.05) inhibition of the carrageenan-induced paw oedema, cotton pellet granuloma, and exhibited an anti-arthritic activity in rats. Vascular permeability induced by acetic acid in the peritoneum of mice was also inhibited. The extract also produced marked analgesic activity by reduction of writhings induced by acetic acid, as well as the early and late phases of paw licking in mice. A significant (P<0.05) reduction in hyperpyrexia in mice was also produced by the extract. This study has established anti-inflammatory, analgesic and antipyretic activities of the stem bark of A. boonei. Copyright (C) 2000 Elsevier Science Ireland Ltd.

LanguageEnglish
Pages179-186
Number of pages8
JournalJournal of Ethnopharmacology
Volume71
Issue number1-2
DOIs
Publication statusPublished - 1 Jul 2000
Externally publishedYes

Fingerprint

Alstonia
Antipyretics
Non-Steroidal Anti-Inflammatory Agents
Acetic Acid
Analgesics
Carrageenan
Peritoneum
Capillary Permeability
Granuloma
Arthritis
Methanol
Edema
Anti-Inflammatory Agents

Cite this

Olajide, Olumayokun A. ; Awe, S. Olubusayo ; Makinde, J. Modupe ; Ekhelar, Ambrose I. ; Olusola, Akin ; Morebise, Olugbenga ; Okpako, David T. / Studies on the anti-inflammatory, antipyretic and analgesic properties of Alstonia boonei stem bark. In: Journal of Ethnopharmacology. 2000 ; Vol. 71, No. 1-2. pp. 179-186.
@article{e3a254744ae644ccad3478b769882870,
title = "Studies on the anti-inflammatory, antipyretic and analgesic properties of Alstonia boonei stem bark",
abstract = "The methanol extract of the stem bark of Alstonia boonei was investigated for anti-inflammatory property. The analgesic and antipyretic properties of the extract was also evaluated. The extract caused a significant (P<0.05) inhibition of the carrageenan-induced paw oedema, cotton pellet granuloma, and exhibited an anti-arthritic activity in rats. Vascular permeability induced by acetic acid in the peritoneum of mice was also inhibited. The extract also produced marked analgesic activity by reduction of writhings induced by acetic acid, as well as the early and late phases of paw licking in mice. A significant (P<0.05) reduction in hyperpyrexia in mice was also produced by the extract. This study has established anti-inflammatory, analgesic and antipyretic activities of the stem bark of A. boonei. Copyright (C) 2000 Elsevier Science Ireland Ltd.",
keywords = "Alstonia boonei De Wild, Analgesic, Anti-inflammatory, Antipyretic",
author = "Olajide, {Olumayokun A.} and Awe, {S. Olubusayo} and Makinde, {J. Modupe} and Ekhelar, {Ambrose I.} and Akin Olusola and Olugbenga Morebise and Okpako, {David T.}",
year = "2000",
month = "7",
day = "1",
doi = "10.1016/S0378-8741(99)00200-7",
language = "English",
volume = "71",
pages = "179--186",
journal = "Journal of Ethnopharmacology",
issn = "0378-8741",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

Studies on the anti-inflammatory, antipyretic and analgesic properties of Alstonia boonei stem bark. / Olajide, Olumayokun A.; Awe, S. Olubusayo; Makinde, J. Modupe; Ekhelar, Ambrose I.; Olusola, Akin; Morebise, Olugbenga; Okpako, David T.

In: Journal of Ethnopharmacology, Vol. 71, No. 1-2, 01.07.2000, p. 179-186.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Studies on the anti-inflammatory, antipyretic and analgesic properties of Alstonia boonei stem bark

AU - Olajide, Olumayokun A.

AU - Awe, S. Olubusayo

AU - Makinde, J. Modupe

AU - Ekhelar, Ambrose I.

AU - Olusola, Akin

AU - Morebise, Olugbenga

AU - Okpako, David T.

PY - 2000/7/1

Y1 - 2000/7/1

N2 - The methanol extract of the stem bark of Alstonia boonei was investigated for anti-inflammatory property. The analgesic and antipyretic properties of the extract was also evaluated. The extract caused a significant (P<0.05) inhibition of the carrageenan-induced paw oedema, cotton pellet granuloma, and exhibited an anti-arthritic activity in rats. Vascular permeability induced by acetic acid in the peritoneum of mice was also inhibited. The extract also produced marked analgesic activity by reduction of writhings induced by acetic acid, as well as the early and late phases of paw licking in mice. A significant (P<0.05) reduction in hyperpyrexia in mice was also produced by the extract. This study has established anti-inflammatory, analgesic and antipyretic activities of the stem bark of A. boonei. Copyright (C) 2000 Elsevier Science Ireland Ltd.

AB - The methanol extract of the stem bark of Alstonia boonei was investigated for anti-inflammatory property. The analgesic and antipyretic properties of the extract was also evaluated. The extract caused a significant (P<0.05) inhibition of the carrageenan-induced paw oedema, cotton pellet granuloma, and exhibited an anti-arthritic activity in rats. Vascular permeability induced by acetic acid in the peritoneum of mice was also inhibited. The extract also produced marked analgesic activity by reduction of writhings induced by acetic acid, as well as the early and late phases of paw licking in mice. A significant (P<0.05) reduction in hyperpyrexia in mice was also produced by the extract. This study has established anti-inflammatory, analgesic and antipyretic activities of the stem bark of A. boonei. Copyright (C) 2000 Elsevier Science Ireland Ltd.

KW - Alstonia boonei De Wild

KW - Analgesic

KW - Anti-inflammatory

KW - Antipyretic

UR - http://www.scopus.com/inward/record.url?scp=0033916982&partnerID=8YFLogxK

U2 - 10.1016/S0378-8741(99)00200-7

DO - 10.1016/S0378-8741(99)00200-7

M3 - Article

VL - 71

SP - 179

EP - 186

JO - Journal of Ethnopharmacology

T2 - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

SN - 0378-8741

IS - 1-2

ER -