Abstract
The methanol extract of the stem bark of Alstonia boonei was investigated for anti-inflammatory property. The analgesic and antipyretic properties of the extract was also evaluated. The extract caused a significant (P<0.05) inhibition of the carrageenan-induced paw oedema, cotton pellet granuloma, and exhibited an anti-arthritic activity in rats. Vascular permeability induced by acetic acid in the peritoneum of mice was also inhibited. The extract also produced marked analgesic activity by reduction of writhings induced by acetic acid, as well as the early and late phases of paw licking in mice. A significant (P<0.05) reduction in hyperpyrexia in mice was also produced by the extract. This study has established anti-inflammatory, analgesic and antipyretic activities of the stem bark of A. boonei. Copyright (C) 2000 Elsevier Science Ireland Ltd.
| Language | English |
|---|---|
| Pages | 179-186 |
| Number of pages | 8 |
| Journal | Journal of Ethnopharmacology |
| Volume | 71 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 1 Jul 2000 |
| Externally published | Yes |
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Studies on the anti-inflammatory, antipyretic and analgesic properties of Alstonia boonei stem bark. / Olajide, Olumayokun A.; Awe, S. Olubusayo; Makinde, J. Modupe; Ekhelar, Ambrose I.; Olusola, Akin; Morebise, Olugbenga; Okpako, David T.
In: Journal of Ethnopharmacology, Vol. 71, No. 1-2, 01.07.2000, p. 179-186.Research output: Contribution to journal › Article
TY - JOUR
T1 - Studies on the anti-inflammatory, antipyretic and analgesic properties of Alstonia boonei stem bark
AU - Olajide, Olumayokun A.
AU - Awe, S. Olubusayo
AU - Makinde, J. Modupe
AU - Ekhelar, Ambrose I.
AU - Olusola, Akin
AU - Morebise, Olugbenga
AU - Okpako, David T.
PY - 2000/7/1
Y1 - 2000/7/1
N2 - The methanol extract of the stem bark of Alstonia boonei was investigated for anti-inflammatory property. The analgesic and antipyretic properties of the extract was also evaluated. The extract caused a significant (P<0.05) inhibition of the carrageenan-induced paw oedema, cotton pellet granuloma, and exhibited an anti-arthritic activity in rats. Vascular permeability induced by acetic acid in the peritoneum of mice was also inhibited. The extract also produced marked analgesic activity by reduction of writhings induced by acetic acid, as well as the early and late phases of paw licking in mice. A significant (P<0.05) reduction in hyperpyrexia in mice was also produced by the extract. This study has established anti-inflammatory, analgesic and antipyretic activities of the stem bark of A. boonei. Copyright (C) 2000 Elsevier Science Ireland Ltd.
AB - The methanol extract of the stem bark of Alstonia boonei was investigated for anti-inflammatory property. The analgesic and antipyretic properties of the extract was also evaluated. The extract caused a significant (P<0.05) inhibition of the carrageenan-induced paw oedema, cotton pellet granuloma, and exhibited an anti-arthritic activity in rats. Vascular permeability induced by acetic acid in the peritoneum of mice was also inhibited. The extract also produced marked analgesic activity by reduction of writhings induced by acetic acid, as well as the early and late phases of paw licking in mice. A significant (P<0.05) reduction in hyperpyrexia in mice was also produced by the extract. This study has established anti-inflammatory, analgesic and antipyretic activities of the stem bark of A. boonei. Copyright (C) 2000 Elsevier Science Ireland Ltd.
KW - Alstonia boonei De Wild
KW - Analgesic
KW - Anti-inflammatory
KW - Antipyretic
UR - http://www.scopus.com/inward/record.url?scp=0033916982&partnerID=8YFLogxK
U2 - 10.1016/S0378-8741(99)00200-7
DO - 10.1016/S0378-8741(99)00200-7
M3 - Article
VL - 71
SP - 179
EP - 186
JO - Journal of Ethnopharmacology
T2 - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
SN - 0378-8741
IS - 1-2
ER -