Studies on the anti-inflammatory, antipyretic and analgesic properties of Alstonia boonei stem bark

Olumayokun A. Olajide; S. Olubusayo Awe; J. Modupe Makinde; Ambrose I. Ekhelar; Akin Olusola; Olugbenga Morebise; David T. Okpako

doi:10.1016/S0378-8741(99)00200-7

Studies on the anti-inflammatory, antipyretic and analgesic properties of Alstonia boonei stem bark

Olumayokun A. Olajide, S. Olubusayo Awe, J. Modupe Makinde, Ambrose I. Ekhelar, Akin Olusola, Olugbenga Morebise, David T. Okpako

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Abstract

The methanol extract of the stem bark of Alstonia boonei was investigated for anti-inflammatory property. The analgesic and antipyretic properties of the extract was also evaluated. The extract caused a significant (P<0.05) inhibition of the carrageenan-induced paw oedema, cotton pellet granuloma, and exhibited an anti-arthritic activity in rats. Vascular permeability induced by acetic acid in the peritoneum of mice was also inhibited. The extract also produced marked analgesic activity by reduction of writhings induced by acetic acid, as well as the early and late phases of paw licking in mice. A significant (P<0.05) reduction in hyperpyrexia in mice was also produced by the extract. This study has established anti-inflammatory, analgesic and antipyretic activities of the stem bark of A. boonei. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	179-186
Number of pages	8
Journal	Journal of Ethnopharmacology
Volume	71
Issue number	1-2
DOIs	https://doi.org/10.1016/S0378-8741(99)00200-7
Publication status	Published - 1 Jul 2000
Externally published	Yes

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title = "Studies on the anti-inflammatory, antipyretic and analgesic properties of Alstonia boonei stem bark",

abstract = "The methanol extract of the stem bark of Alstonia boonei was investigated for anti-inflammatory property. The analgesic and antipyretic properties of the extract was also evaluated. The extract caused a significant (P<0.05) inhibition of the carrageenan-induced paw oedema, cotton pellet granuloma, and exhibited an anti-arthritic activity in rats. Vascular permeability induced by acetic acid in the peritoneum of mice was also inhibited. The extract also produced marked analgesic activity by reduction of writhings induced by acetic acid, as well as the early and late phases of paw licking in mice. A significant (P<0.05) reduction in hyperpyrexia in mice was also produced by the extract. This study has established anti-inflammatory, analgesic and antipyretic activities of the stem bark of A. boonei. Copyright (C) 2000 Elsevier Science Ireland Ltd.",

keywords = "Alstonia boonei De Wild, Analgesic, Anti-inflammatory, Antipyretic",

author = "Olajide, {Olumayokun A.} and Awe, {S. Olubusayo} and Makinde, {J. Modupe} and Ekhelar, {Ambrose I.} and Akin Olusola and Olugbenga Morebise and Okpako, {David T.}",

year = "2000",

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doi = "10.1016/S0378-8741(99)00200-7",

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AU - Olajide, Olumayokun A.

AU - Awe, S. Olubusayo

AU - Makinde, J. Modupe

AU - Ekhelar, Ambrose I.

AU - Olusola, Akin

AU - Morebise, Olugbenga

AU - Okpako, David T.

PY - 2000/7/1

Y1 - 2000/7/1

N2 - The methanol extract of the stem bark of Alstonia boonei was investigated for anti-inflammatory property. The analgesic and antipyretic properties of the extract was also evaluated. The extract caused a significant (P<0.05) inhibition of the carrageenan-induced paw oedema, cotton pellet granuloma, and exhibited an anti-arthritic activity in rats. Vascular permeability induced by acetic acid in the peritoneum of mice was also inhibited. The extract also produced marked analgesic activity by reduction of writhings induced by acetic acid, as well as the early and late phases of paw licking in mice. A significant (P<0.05) reduction in hyperpyrexia in mice was also produced by the extract. This study has established anti-inflammatory, analgesic and antipyretic activities of the stem bark of A. boonei. Copyright (C) 2000 Elsevier Science Ireland Ltd.

AB - The methanol extract of the stem bark of Alstonia boonei was investigated for anti-inflammatory property. The analgesic and antipyretic properties of the extract was also evaluated. The extract caused a significant (P<0.05) inhibition of the carrageenan-induced paw oedema, cotton pellet granuloma, and exhibited an anti-arthritic activity in rats. Vascular permeability induced by acetic acid in the peritoneum of mice was also inhibited. The extract also produced marked analgesic activity by reduction of writhings induced by acetic acid, as well as the early and late phases of paw licking in mice. A significant (P<0.05) reduction in hyperpyrexia in mice was also produced by the extract. This study has established anti-inflammatory, analgesic and antipyretic activities of the stem bark of A. boonei. Copyright (C) 2000 Elsevier Science Ireland Ltd.

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KW - Antipyretic

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