TY - JOUR
T1 - Studies on the molecular flexibility of novel dendronized carboxymethyl cellulose derivatives
AU - Pohl, Matthias
AU - Morris, Gordon A.
AU - Harding, Steve E.
AU - Heinze, Thomas
PY - 2009/4
Y1 - 2009/4
N2 - Water-soluble deoxy-azido cellulose derivatives were synthesized by heterogeneous carboxymethylation, applying 2-propanol/aqueous NaOH as slurry medium. The novel, carboxymethyl deoxy-azido cellulose provides a convenient starting material for the selective dendronization of cellulose via the copper-catalyzed Huisgen reaction yielding water-soluble carboxymethyl 6-deoxy-(1-N-[1,2,3-triazolo]-4-polyamidoamine) cellulose derivatives of first (degree of substitution, DS 0.51), second (DS 0.44) and third generation (DS 0.39). The novel biopolymer derivatives were characterized by FT-IR and NMR spectroscopy, intrinsic viscosity, sedimentation coefficient and weight average molar mass. Solution conformation and flexibility were estimated qualitatively using conformation zoning and quantitatively (persistence length) using the combined global method. Sedimentation conformation zoning showed a semi-flexible coil conformation and the global method applied to each carboxymethyl deoxy-azido cellulose and carboxymethyl 6-deoxy-(1-N-[1,2,3-triazolo]-4-polyamidoamine) cellulose derivative yielded persistence length all within the range of 2.8-4.0 nm with no evidence of any change in flexibility with dendronization.
AB - Water-soluble deoxy-azido cellulose derivatives were synthesized by heterogeneous carboxymethylation, applying 2-propanol/aqueous NaOH as slurry medium. The novel, carboxymethyl deoxy-azido cellulose provides a convenient starting material for the selective dendronization of cellulose via the copper-catalyzed Huisgen reaction yielding water-soluble carboxymethyl 6-deoxy-(1-N-[1,2,3-triazolo]-4-polyamidoamine) cellulose derivatives of first (degree of substitution, DS 0.51), second (DS 0.44) and third generation (DS 0.39). The novel biopolymer derivatives were characterized by FT-IR and NMR spectroscopy, intrinsic viscosity, sedimentation coefficient and weight average molar mass. Solution conformation and flexibility were estimated qualitatively using conformation zoning and quantitatively (persistence length) using the combined global method. Sedimentation conformation zoning showed a semi-flexible coil conformation and the global method applied to each carboxymethyl deoxy-azido cellulose and carboxymethyl 6-deoxy-(1-N-[1,2,3-triazolo]-4-polyamidoamine) cellulose derivative yielded persistence length all within the range of 2.8-4.0 nm with no evidence of any change in flexibility with dendronization.
KW - Cellulose
KW - Conformation analysis
KW - Dendronization
KW - Dendronized cellulose
KW - Polysaccharides
KW - Ultracentrifugation
UR - http://www.scopus.com/inward/record.url?scp=61349158011&partnerID=8YFLogxK
UR - https://www.journals.elsevier.com/european-polymer-journal
U2 - 10.1016/j.eurpolymj.2009.01.009
DO - 10.1016/j.eurpolymj.2009.01.009
M3 - Article
AN - SCOPUS:61349158011
VL - 45
SP - 1098
EP - 1110
JO - European Polymer Journal
JF - European Polymer Journal
SN - 0014-3057
IS - 4
ER -