Study of dissolution hydrodynamic conditions versus drug release from hypromellose matrices: The influence of agitation sequence

Kofi Asare-Addo, Marina Levina, Ali R. Rajabi-Siahboomi, Ali Nokhodchi

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

In this article, the influence of agitation in descending and ascending sequences as a systematic method development process for potentially discriminating fed and fasted states and evaluation of its effects on the drug release from swelling gel-forming hydrophilic matrix tablets were investigated. Theophylline extended release (ER) matrices containing hypromellose (hydroxypropyl methylcellulose (HPMC)) were evaluated in media with a pH range of 1.2-7.5, using an automated USP type III, Bio-Dis dissolution apparatus at 5, 10, 15, 20, 25 and 30 dips per minute (dpm). Agitation had a profound effect on the drug release from the HPMC K100LV matrices. Drug release in pH 1.2 changed from about 40% at 5dpm to about 80% at 30dpm over a 60min period alone. The matrices containing HPMC K4M, K15M and K100M however were not significantly affected by the agitation rate. The similarity factor f2 was calculated using drug release at 10dpm as a reference. The ascending agitations of 5-30dpm and the descending order of agitation 30-5dpm were also evaluated. Anomalous transport was the only kinetic of release for the K4M, K15M and K100M tablet matrices. The lower viscous polymer of K100LV had some matrices exhibiting Fickian diffusion as its kinetics of release. The use of systematic change of agitation method may indicate potential fed and fasted effects on drug release from hydrophilic matrices.

LanguageEnglish
Pages452-460
Number of pages9
JournalColloids and Surfaces B: Biointerfaces
Volume81
Issue number2
Early online date23 Jul 2010
DOIs
Publication statusPublished - 1 Dec 2010
Externally publishedYes

Fingerprint

agitation
Hydrodynamics
dissolving
Dissolution
drugs
hydrodynamics
Kinetics
matrices
Pharmaceutical Preparations
Swelling
Gels
Tablets
tablets
Polymers
Theophylline
kinetics
hydroxypropylmethylcellulose-lactose matrix
Hypromellose Derivatives
Drug Liberation
swelling

Cite this

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abstract = "In this article, the influence of agitation in descending and ascending sequences as a systematic method development process for potentially discriminating fed and fasted states and evaluation of its effects on the drug release from swelling gel-forming hydrophilic matrix tablets were investigated. Theophylline extended release (ER) matrices containing hypromellose (hydroxypropyl methylcellulose (HPMC)) were evaluated in media with a pH range of 1.2-7.5, using an automated USP type III, Bio-Dis dissolution apparatus at 5, 10, 15, 20, 25 and 30 dips per minute (dpm). Agitation had a profound effect on the drug release from the HPMC K100LV matrices. Drug release in pH 1.2 changed from about 40{\%} at 5dpm to about 80{\%} at 30dpm over a 60min period alone. The matrices containing HPMC K4M, K15M and K100M however were not significantly affected by the agitation rate. The similarity factor f2 was calculated using drug release at 10dpm as a reference. The ascending agitations of 5-30dpm and the descending order of agitation 30-5dpm were also evaluated. Anomalous transport was the only kinetic of release for the K4M, K15M and K100M tablet matrices. The lower viscous polymer of K100LV had some matrices exhibiting Fickian diffusion as its kinetics of release. The use of systematic change of agitation method may indicate potential fed and fasted effects on drug release from hydrophilic matrices.",
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Study of dissolution hydrodynamic conditions versus drug release from hypromellose matrices : The influence of agitation sequence. / Asare-Addo, Kofi; Levina, Marina; Rajabi-Siahboomi, Ali R.; Nokhodchi, Ali.

In: Colloids and Surfaces B: Biointerfaces, Vol. 81, No. 2, 01.12.2010, p. 452-460.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Study of dissolution hydrodynamic conditions versus drug release from hypromellose matrices

T2 - Colloids and Surfaces B: Biointerfaces

AU - Asare-Addo, Kofi

AU - Levina, Marina

AU - Rajabi-Siahboomi, Ali R.

AU - Nokhodchi, Ali

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