Sulfated polysaccharides: Immunomodulation and signaling mechanisms

Lixin Huang, Mingyue Shen, Gordon Morris, Jianhua Xie

Research output: Contribution to journalReview article

Abstract

Background
Polysaccharides are natural macromolecular polymers that are widely distributed in various food resources and have attracted much attention due to their significant bioactivities. Sulfated polysaccharides refer to polysaccharides containing sulfate groups on sugar units. A large number of studies have characterized and evaluated the biological relevance of sulfated polysaccharides, which shows great potential in terms of immunological activity.

Scope and approach
Through a critical analysis of current research literature regarding sulfated polysaccharides, this review will give an overview of the immunomodulatory properties and signaling mechanisms of natural or modified sulfated polysaccharides. The effects of the degree of substitution (DS), molecular weight, and structure on immunomodulatory effects will also be discussed.

Key findings and conclusions
The mechanisms by which sulfated polysaccharides exert their immunological activity is mainly due to the regulation of macrophage function, natural killer cells, and T/B lymphocytes, together with the stimulation of the immune responses of lymphocytes and the activation of the complement system. The immunological activity of sulfated polysaccharides depends not only on the source of the polysaccharide but also on structural characteristics, such as molecular weight and DS. Studies on the mechanisms of immune function have shown that the action of sulfated polysaccharides is a complex process that may be regulated by one or more pathways. Nevertheless, the link between the immunological mechanisms and structure of sulfated polysaccharides requires further exploration.
LanguageEnglish
Pages1-11
Number of pages11
JournalTrends in Food Science and Technology
Volume92
Early online date13 Aug 2019
DOIs
Publication statusE-pub ahead of print - 13 Aug 2019

Fingerprint

immunomodulation
Immunomodulation
Polysaccharides
polysaccharides
Molecular Weight
molecular weight
Natural Killer T-Cells
natural killer cells
Lymphocyte Activation
Molecular Structure
chemical structure
Sulfates
B-lymphocytes
polymers
sulfates
Polymers
complement
macrophages
B-Lymphocytes
lymphocytes

Cite this

@article{7bcc281300734b88926cf19be0604129,
title = "Sulfated polysaccharides: Immunomodulation and signaling mechanisms",
abstract = "BackgroundPolysaccharides are natural macromolecular polymers that are widely distributed in various food resources and have attracted much attention due to their significant bioactivities. Sulfated polysaccharides refer to polysaccharides containing sulfate groups on sugar units. A large number of studies have characterized and evaluated the biological relevance of sulfated polysaccharides, which shows great potential in terms of immunological activity.Scope and approachThrough a critical analysis of current research literature regarding sulfated polysaccharides, this review will give an overview of the immunomodulatory properties and signaling mechanisms of natural or modified sulfated polysaccharides. The effects of the degree of substitution (DS), molecular weight, and structure on immunomodulatory effects will also be discussed.Key findings and conclusionsThe mechanisms by which sulfated polysaccharides exert their immunological activity is mainly due to the regulation of macrophage function, natural killer cells, and T/B lymphocytes, together with the stimulation of the immune responses of lymphocytes and the activation of the complement system. The immunological activity of sulfated polysaccharides depends not only on the source of the polysaccharide but also on structural characteristics, such as molecular weight and DS. Studies on the mechanisms of immune function have shown that the action of sulfated polysaccharides is a complex process that may be regulated by one or more pathways. Nevertheless, the link between the immunological mechanisms and structure of sulfated polysaccharides requires further exploration.",
keywords = "Sulfated polysaccharide, Immunity, mechanism, Mechanism",
author = "Lixin Huang and Mingyue Shen and Gordon Morris and Jianhua Xie",
year = "2019",
month = "8",
day = "13",
doi = "10.1016/j.tifs.2019.08.008",
language = "English",
volume = "92",
pages = "1--11",
journal = "Trends in Food Science and Technology",
issn = "0924-2244",
publisher = "Elsevier Limited",

}

Sulfated polysaccharides : Immunomodulation and signaling mechanisms. / Huang, Lixin; Shen, Mingyue; Morris, Gordon; Xie, Jianhua.

In: Trends in Food Science and Technology, Vol. 92, 01.10.2019, p. 1-11.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Sulfated polysaccharides

T2 - Trends in Food Science and Technology

AU - Huang, Lixin

AU - Shen, Mingyue

AU - Morris, Gordon

AU - Xie, Jianhua

PY - 2019/8/13

Y1 - 2019/8/13

N2 - BackgroundPolysaccharides are natural macromolecular polymers that are widely distributed in various food resources and have attracted much attention due to their significant bioactivities. Sulfated polysaccharides refer to polysaccharides containing sulfate groups on sugar units. A large number of studies have characterized and evaluated the biological relevance of sulfated polysaccharides, which shows great potential in terms of immunological activity.Scope and approachThrough a critical analysis of current research literature regarding sulfated polysaccharides, this review will give an overview of the immunomodulatory properties and signaling mechanisms of natural or modified sulfated polysaccharides. The effects of the degree of substitution (DS), molecular weight, and structure on immunomodulatory effects will also be discussed.Key findings and conclusionsThe mechanisms by which sulfated polysaccharides exert their immunological activity is mainly due to the regulation of macrophage function, natural killer cells, and T/B lymphocytes, together with the stimulation of the immune responses of lymphocytes and the activation of the complement system. The immunological activity of sulfated polysaccharides depends not only on the source of the polysaccharide but also on structural characteristics, such as molecular weight and DS. Studies on the mechanisms of immune function have shown that the action of sulfated polysaccharides is a complex process that may be regulated by one or more pathways. Nevertheless, the link between the immunological mechanisms and structure of sulfated polysaccharides requires further exploration.

AB - BackgroundPolysaccharides are natural macromolecular polymers that are widely distributed in various food resources and have attracted much attention due to their significant bioactivities. Sulfated polysaccharides refer to polysaccharides containing sulfate groups on sugar units. A large number of studies have characterized and evaluated the biological relevance of sulfated polysaccharides, which shows great potential in terms of immunological activity.Scope and approachThrough a critical analysis of current research literature regarding sulfated polysaccharides, this review will give an overview of the immunomodulatory properties and signaling mechanisms of natural or modified sulfated polysaccharides. The effects of the degree of substitution (DS), molecular weight, and structure on immunomodulatory effects will also be discussed.Key findings and conclusionsThe mechanisms by which sulfated polysaccharides exert their immunological activity is mainly due to the regulation of macrophage function, natural killer cells, and T/B lymphocytes, together with the stimulation of the immune responses of lymphocytes and the activation of the complement system. The immunological activity of sulfated polysaccharides depends not only on the source of the polysaccharide but also on structural characteristics, such as molecular weight and DS. Studies on the mechanisms of immune function have shown that the action of sulfated polysaccharides is a complex process that may be regulated by one or more pathways. Nevertheless, the link between the immunological mechanisms and structure of sulfated polysaccharides requires further exploration.

KW - Sulfated polysaccharide

KW - Immunity

KW - mechanism

KW - Mechanism

UR - http://www.scopus.com/inward/record.url?scp=85070641123&partnerID=8YFLogxK

U2 - 10.1016/j.tifs.2019.08.008

DO - 10.1016/j.tifs.2019.08.008

M3 - Review article

VL - 92

SP - 1

EP - 11

JO - Trends in Food Science and Technology

JF - Trends in Food Science and Technology

SN - 0924-2244

ER -