Synthesis and anti-tumour activity of 6-methyl derivatives of flavone-8-acetic acid (FAA)

R. Alan Aitken, Michael C. Bibby, John A. Double, Roger M. Phillips, Shiv Kumar Sharma

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A range of 16 derivatives of flavone-8-acetic acid (FAA) with a 6-methyl substituent have been prepared and their anti-tumour activity evaluted in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. While many of the compounds show activity comparable to FAA in vitro, this essentially disappears in vivo, possibly due to degradation before the compounds can reach the tumour site.

Original languageEnglish
Pages (from-to)2313-2316
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume4
Issue number19
DOIs
Publication statusPublished - 6 Oct 1994
Externally publishedYes

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flavone acetic acid
Tumors
Derivatives
Tumor Cell Line
Neoplasms
Cells
Degradation
In Vitro Techniques

Cite this

Aitken, R. Alan ; Bibby, Michael C. ; Double, John A. ; Phillips, Roger M. ; Sharma, Shiv Kumar. / Synthesis and anti-tumour activity of 6-methyl derivatives of flavone-8-acetic acid (FAA). In: Bioorganic and Medicinal Chemistry Letters. 1994 ; Vol. 4, No. 19. pp. 2313-2316.
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Synthesis and anti-tumour activity of 6-methyl derivatives of flavone-8-acetic acid (FAA). / Aitken, R. Alan; Bibby, Michael C.; Double, John A.; Phillips, Roger M.; Sharma, Shiv Kumar.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 4, No. 19, 06.10.1994, p. 2313-2316.

Research output: Contribution to journalArticle

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