Synthesis and anticancer activity evaluation of η5-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands

A. Rodríguez-Bárzano, R. M. Lord, A. M. Basri, R. M. Phillips, A. J. Blacker, P. C. McGowan

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The complexes [RuCp∗(PP)Cl] (Cp∗ = C5Me5; [1], PP = dppm; [4], PP = Xantphos), [RuCp#(PP)Cl] (Cp# = C5Me4(CH2)5OH; [2], PP = dppm; [5], PP = Xantphos) and [RuCp∗(dppm)(CH3CN)][SbF6] [3] were synthesized and evaluated in vitro as anticancer agents. Compounds 1-3 gave nanomolar IC50 values against normoxic A2780 and HT-29 cell lines, and were also tested against hypoxic HT-29 cells, maintaining their high activity. Complex 3 yielded an IC50 value of 0.55 ± 0.03 μM under a 0.1% O2 concentration.

Original languageEnglish
Pages (from-to)3265-3270
Number of pages6
JournalDalton Transactions
Volume44
Issue number7
DOIs
Publication statusPublished - 5 Jan 2015
Externally publishedYes

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