Synthesis and anticancer activity evaluation of η5-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands

A. Rodríguez-Bárzano; R. M. Lord; A. M. Basri; R. M. Phillips; A. J. Blacker; P. C. McGowan

doi:10.1039/c4dt02748e

Synthesis and anticancer activity evaluation of η⁵-C₅(CH₃)₄R ruthenium complexes bearing chelating diphosphine ligands

A. Rodríguez-Bárzano, R. M. Lord, A. M. Basri, R. M. Phillips, A. J. Blacker, P. C. McGowan

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The complexes [RuCp∗(PP)Cl] (Cp∗ = C₅Me₅; [1], PP = dppm; [4], PP = Xantphos), [RuCp^#(PP)Cl] (Cp^# = C₅Me₄(CH₂)₅OH; [2], PP = dppm; [5], PP = Xantphos) and [RuCp∗(dppm)(CH₃CN)][SbF₆] [3] were synthesized and evaluated in vitro as anticancer agents. Compounds 1-3 gave nanomolar IC₅₀ values against normoxic A2780 and HT-29 cell lines, and were also tested against hypoxic HT-29 cells, maintaining their high activity. Complex 3 yielded an IC₅₀ value of 0.55 ± 0.03 μM under a 0.1% O₂ concentration.

Original language	English
Pages (from-to)	3265-3270
Number of pages	6
Journal	Dalton Transactions
Volume	44
Issue number	7
DOIs	https://doi.org/10.1039/c4dt02748e
Publication status	Published - 5 Jan 2015
Externally published	Yes

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title = "Synthesis and anticancer activity evaluation of η5-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands",

abstract = "The complexes [RuCp∗(PP)Cl] (Cp∗ = C5Me5; [1], PP = dppm; [4], PP = Xantphos), [RuCp\#(PP)Cl] (Cp\# = C5Me4(CH2)5OH; [2], PP = dppm; [5], PP = Xantphos) and [RuCp∗(dppm)(CH3CN)][SbF6] [3] were synthesized and evaluated in vitro as anticancer agents. Compounds 1-3 gave nanomolar IC50 values against normoxic A2780 and HT-29 cell lines, and were also tested against hypoxic HT-29 cells, maintaining their high activity. Complex 3 yielded an IC50 value of 0.55 ± 0.03 μM under a 0.1\% O2 concentration.",

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month = jan,

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doi = "10.1039/c4dt02748e",

language = "English",

volume = "44",

pages = "3265--3270",

journal = "Dalton Transactions",

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T1 - Synthesis and anticancer activity evaluation of η5-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands

AU - Rodríguez-Bárzano, A.

AU - Lord, R. M.

AU - Basri, A. M.

AU - Phillips, R. M.

AU - Blacker, A. J.

AU - McGowan, P. C.

PY - 2015/1/5

Y1 - 2015/1/5

N2 - The complexes [RuCp∗(PP)Cl] (Cp∗ = C5Me5; [1], PP = dppm; [4], PP = Xantphos), [RuCp#(PP)Cl] (Cp# = C5Me4(CH2)5OH; [2], PP = dppm; [5], PP = Xantphos) and [RuCp∗(dppm)(CH3CN)][SbF6] [3] were synthesized and evaluated in vitro as anticancer agents. Compounds 1-3 gave nanomolar IC50 values against normoxic A2780 and HT-29 cell lines, and were also tested against hypoxic HT-29 cells, maintaining their high activity. Complex 3 yielded an IC50 value of 0.55 ± 0.03 μM under a 0.1% O2 concentration.

AB - The complexes [RuCp∗(PP)Cl] (Cp∗ = C5Me5; [1], PP = dppm; [4], PP = Xantphos), [RuCp#(PP)Cl] (Cp# = C5Me4(CH2)5OH; [2], PP = dppm; [5], PP = Xantphos) and [RuCp∗(dppm)(CH3CN)][SbF6] [3] were synthesized and evaluated in vitro as anticancer agents. Compounds 1-3 gave nanomolar IC50 values against normoxic A2780 and HT-29 cell lines, and were also tested against hypoxic HT-29 cells, maintaining their high activity. Complex 3 yielded an IC50 value of 0.55 ± 0.03 μM under a 0.1% O2 concentration.

UR - https://www.scopus.com/pages/publications/84922675469

U2 - 10.1039/c4dt02748e

DO - 10.1039/c4dt02748e

M3 - Article

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AN - SCOPUS:84922675469

SN - 1477-9226

VL - 44

SP - 3265

EP - 3270

JO - Dalton Transactions

JF - Dalton Transactions

IS - 7

ER -

Synthesis and anticancer activity evaluation of η⁵-C₅(CH₃)₄R ruthenium complexes bearing chelating diphosphine ligands

Abstract

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