Synthesis and Antioxidant Activities of Novel Chiral Ebselen Analogues

Mohamed Elsherbini, Wafaa S. Hamama, Hanafi H. Zoorob, Debasish Bhowmick, Govindasamy Mugesh, Thomas Wirth

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Abstract

Novel chiral analogues of the antioxidant, anti‐inflammatory organoselenium drug ebselen were synthesized. The reaction proceeded readily from 2‐(chloroseleno)benzoyl chloride with chiral amino compounds. The chiral substituent on the nitrogen atom did not provide a substantial increase in activities and the newly synthesized compounds showed similar activities to ebselen.
Original languageEnglish
Pages (from-to)320-325
Number of pages6
JournalHeteroatom Chemistry
Volume25
Issue number5
Early online date9 May 2014
DOIs
Publication statusPublished - Nov 2014
Externally publishedYes

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Elsherbini, M., Hamama, W. S., Zoorob, H. H., Bhowmick, D., Mugesh, G., & Wirth, T. (2014). Synthesis and Antioxidant Activities of Novel Chiral Ebselen Analogues. Heteroatom Chemistry, 25(5), 320-325. https://doi.org/10.1002/hc.21164