Novel chiral analogues of the antioxidant, anti‐inflammatory organoselenium drug ebselen were synthesized. The reaction proceeded readily from 2‐(chloroseleno)benzoyl chloride with chiral amino compounds. The chiral substituent on the nitrogen atom did not provide a substantial increase in activities and the newly synthesized compounds showed similar activities to ebselen.
Elsherbini, M., Hamama, W. S., Zoorob, H. H., Bhowmick, D., Mugesh, G., & Wirth, T. (2014). Synthesis and Antioxidant Activities of Novel Chiral Ebselen Analogues. Heteroatom Chemistry, 25(5), 320-325. https://doi.org/10.1002/hc.21164