Synthesis and Antioxidant Activities of Novel Chiral Ebselen Analogues

Mohamed Elsherbini, Wafaa S. Hamama, Hanafi H. Zoorob, Debasish Bhowmick, Govindasamy Mugesh, Thomas Wirth

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Novel chiral analogues of the antioxidant, anti‐inflammatory organoselenium drug ebselen were synthesized. The reaction proceeded readily from 2‐(chloroseleno)benzoyl chloride with chiral amino compounds. The chiral substituent on the nitrogen atom did not provide a substantial increase in activities and the newly synthesized compounds showed similar activities to ebselen.
Original languageEnglish
Pages (from-to)320-325
Number of pages6
JournalHeteroatom Chemistry
Volume25
Issue number5
Early online date9 May 2014
DOIs
Publication statusPublished - Nov 2014
Externally publishedYes

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Antioxidants
Anti-Inflammatory Agents
Nitrogen
Atoms
Pharmaceutical Preparations
ebselen
benzoyl chloride

Cite this

Elsherbini, M., Hamama, W. S., Zoorob, H. H., Bhowmick, D., Mugesh, G., & Wirth, T. (2014). Synthesis and Antioxidant Activities of Novel Chiral Ebselen Analogues. Heteroatom Chemistry, 25(5), 320-325. https://doi.org/10.1002/hc.21164
Elsherbini, Mohamed ; Hamama, Wafaa S. ; Zoorob, Hanafi H. ; Bhowmick, Debasish ; Mugesh, Govindasamy ; Wirth, Thomas. / Synthesis and Antioxidant Activities of Novel Chiral Ebselen Analogues. In: Heteroatom Chemistry. 2014 ; Vol. 25, No. 5. pp. 320-325.
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Elsherbini, M, Hamama, WS, Zoorob, HH, Bhowmick, D, Mugesh, G & Wirth, T 2014, 'Synthesis and Antioxidant Activities of Novel Chiral Ebselen Analogues', Heteroatom Chemistry, vol. 25, no. 5, pp. 320-325. https://doi.org/10.1002/hc.21164

Synthesis and Antioxidant Activities of Novel Chiral Ebselen Analogues. / Elsherbini, Mohamed; Hamama, Wafaa S. ; Zoorob, Hanafi H.; Bhowmick, Debasish; Mugesh, Govindasamy; Wirth, Thomas.

In: Heteroatom Chemistry, Vol. 25, No. 5, 11.2014, p. 320-325.

Research output: Contribution to journalArticle

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