Synthesis and antitumor activity of a series of osmium(IV) nitrido complexes bearing quinolinolato ligands

Quan Tang; Wen Xiu Ni; Chi Fai Leung; Wai Lun Man; Kenneth King Kwan Lau; Yimin Liang; Yun Wah Lam; Wai Yeung Wong; Shie Ming Peng; Gui Jian Liu; Tai Chu Lau

doi:10.1039/c3cc42250j

Synthesis and antitumor activity of a series of osmium(IV) nitrido complexes bearing quinolinolato ligands

Quan Tang, Wen Xiu Ni, Chi Fai Leung, Wai Lun Man, Kenneth King Kwan Lau, Yimin Liang, Yun Wah Lam, Wai Yeung Wong, Shie Ming Peng, Gui Jian Liu, Tai Chu Lau

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

A series of osmium(IV) nitrido complexes supported by quinolinolato ligands have been prepared and they exhibit promising in vitro anti-cancer activities. These results establish that Os^VI≡N is a potentially versatile and promising platform for the design of a variety of high-valent anti-cancer drugs.

Original language	English
Pages (from-to)	9980-9982
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	85
Early online date	28 Aug 2013
DOIs	https://doi.org/10.1039/c3cc42250j
Publication status	Published - 4 Nov 2013
Externally published	Yes

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SDG 3 Good Health and Well-being

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title = "Synthesis and antitumor activity of a series of osmium(IV) nitrido complexes bearing quinolinolato ligands",

abstract = "A series of osmium(IV) nitrido complexes supported by quinolinolato ligands have been prepared and they exhibit promising in vitro anti-cancer activities. These results establish that OsVI≡N is a potentially versatile and promising platform for the design of a variety of high-valent anti-cancer drugs.",

keywords = "antineoplastic agent, cisplatin, osmium derivative, osmium(vi)nitrido complex, quinoline derivative, quinolinolato ligand, unclassified drug",

author = "Quan Tang and Ni, \{Wen Xiu\} and Leung, \{Chi Fai\} and Man, \{Wai Lun\} and Lau, \{Kenneth King Kwan\} and Yimin Liang and Lam, \{Yun Wah\} and Wong, \{Wai Yeung\} and Peng, \{Shie Ming\} and Liu, \{Gui Jian\} and Lau, \{Tai Chu\}",

year = "2013",

month = nov,

day = "4",

doi = "10.1039/c3cc42250j",

language = "English",

volume = "49",

pages = "9980--9982",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "85",

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TY - JOUR

T1 - Synthesis and antitumor activity of a series of osmium(IV) nitrido complexes bearing quinolinolato ligands

AU - Tang, Quan

AU - Ni, Wen Xiu

AU - Leung, Chi Fai

AU - Man, Wai Lun

AU - Lau, Kenneth King Kwan

AU - Liang, Yimin

AU - Lam, Yun Wah

AU - Wong, Wai Yeung

AU - Peng, Shie Ming

AU - Liu, Gui Jian

AU - Lau, Tai Chu

PY - 2013/11/4

Y1 - 2013/11/4

N2 - A series of osmium(IV) nitrido complexes supported by quinolinolato ligands have been prepared and they exhibit promising in vitro anti-cancer activities. These results establish that OsVI≡N is a potentially versatile and promising platform for the design of a variety of high-valent anti-cancer drugs.

AB - A series of osmium(IV) nitrido complexes supported by quinolinolato ligands have been prepared and they exhibit promising in vitro anti-cancer activities. These results establish that OsVI≡N is a potentially versatile and promising platform for the design of a variety of high-valent anti-cancer drugs.

KW - antineoplastic agent

KW - cisplatin

KW - osmium derivative

KW - osmium(vi)nitrido complex

KW - quinoline derivative

KW - quinolinolato ligand

KW - unclassified drug

UR - https://www.scopus.com/pages/publications/84885155074

U2 - 10.1039/c3cc42250j

DO - 10.1039/c3cc42250j

M3 - Article

C2 - 24042270

AN - SCOPUS:84885155074

SN - 1359-7345

VL - 49

SP - 9980

EP - 9982

JO - Chemical Communications

JF - Chemical Communications

IS - 85

ER -

Synthesis and antitumor activity of a series of osmium(IV) nitrido complexes bearing quinolinolato ligands

Abstract

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