Synthesis and Antitumour Activity of New Derivatives of Flavone‐8‐acetic Acid (FAA). Part 1: 6-Methyl Derivatives

R A Aitken, M C Bibby, J A Double, R M Phillips, S K Sharma

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Abstract

A range of 17 derivatives of flavone-8-acetic acid (FAA) with a 6-methyl substituent have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. While many of the compounds show activity comparable to FAA in vitro, this essentially disappears in vivo, possibly due to degradation before the compounds can reach the tumour site.

LanguageEnglish
Pages489-497
Number of pages9
JournalArchiv der Pharmazie
Volume329
Issue number11
DOIs
Publication statusPublished - 1996
Externally publishedYes

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flavone acetic acid
Tumor Cell Line
Neoplasms
In Vitro Techniques

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title = "Synthesis and Antitumour Activity of New Derivatives of Flavone‐8‐acetic Acid (FAA). Part 1: 6-Methyl Derivatives",
abstract = "A range of 17 derivatives of flavone-8-acetic acid (FAA) with a 6-methyl substituent have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. While many of the compounds show activity comparable to FAA in vitro, this essentially disappears in vivo, possibly due to degradation before the compounds can reach the tumour site.",
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Synthesis and Antitumour Activity of New Derivatives of Flavone‐8‐acetic Acid (FAA). Part 1 : 6-Methyl Derivatives. / Aitken, R A; Bibby, M C; Double, J A; Phillips, R M; Sharma, S K.

In: Archiv der Pharmazie, Vol. 329, No. 11, 1996, p. 489-497.

Research output: Contribution to journalArticle

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KW - Flavonoids/chemical synthesis

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