Synthesis and Antitumour Activity of New Derivatives of Flavone‐8‐acetic Acid (FAA). Part 1: 6-Methyl Derivatives

R A Aitken; M C Bibby; J A Double; R M Phillips; S K Sharma

doi:10.1002/ardp.19963291104

Synthesis and Antitumour Activity of New Derivatives of Flavone‐8‐acetic Acid (FAA). Part 1: 6-Methyl Derivatives

R A Aitken, M C Bibby, J A Double, R M Phillips, S K Sharma

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

A range of 17 derivatives of flavone-8-acetic acid (FAA) with a 6-methyl substituent have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. While many of the compounds show activity comparable to FAA in vitro, this essentially disappears in vivo, possibly due to degradation before the compounds can reach the tumour site.

Original language	English
Pages (from-to)	489-497
Number of pages	9
Journal	Archiv der Pharmazie
Volume	329
Issue number	11
DOIs	https://doi.org/10.1002/ardp.19963291104
Publication status	Published - 1996
Externally published	Yes

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title = "Synthesis and Antitumour Activity of New Derivatives of Flavone‐8‐acetic Acid (FAA). Part 1: 6-Methyl Derivatives",

abstract = "A range of 17 derivatives of flavone-8-acetic acid (FAA) with a 6-methyl substituent have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. While many of the compounds show activity comparable to FAA in vitro, this essentially disappears in vivo, possibly due to degradation before the compounds can reach the tumour site.",

keywords = "Animals, Antineoplastic Agents/chemical synthesis, Drug Screening Assays, Antitumor, Flavonoids/chemical synthesis, Humans, Mice, Neoplasm Transplantation, Tumor Cells, Cultured, flavone acetic acid, synthesis, antitumour activity, structure‐activity relationships",

author = "Aitken, {R A} and Bibby, {M C} and Double, {J A} and Phillips, {R M} and Sharma, {S K}",

year = "1996",

doi = "10.1002/ardp.19963291104",

language = "English",

volume = "329",

pages = "489--497",

journal = "Archiv der Pharmazie",

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publisher = "Wiley-VCH Verlag",

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T1 - Synthesis and Antitumour Activity of New Derivatives of Flavone‐8‐acetic Acid (FAA). Part 1

T2 - 6-Methyl Derivatives

AU - Aitken, R A

AU - Bibby, M C

AU - Double, J A

AU - Phillips, R M

AU - Sharma, S K

PY - 1996

Y1 - 1996

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AB - A range of 17 derivatives of flavone-8-acetic acid (FAA) with a 6-methyl substituent have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. While many of the compounds show activity comparable to FAA in vitro, this essentially disappears in vivo, possibly due to degradation before the compounds can reach the tumour site.

KW - Animals

KW - Antineoplastic Agents/chemical synthesis

KW - Drug Screening Assays, Antitumor

KW - Flavonoids/chemical synthesis

KW - Humans

KW - Mice

KW - Neoplasm Transplantation

KW - Tumor Cells, Cultured

KW - flavone acetic acid

KW - synthesis

KW - antitumour activity

KW - structure‐activity relationships

U2 - 10.1002/ardp.19963291104

DO - 10.1002/ardp.19963291104

M3 - Article

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VL - 329

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EP - 497

JO - Archiv der Pharmazie

JF - Archiv der Pharmazie

SN - 0365-6233

IS - 11

ER -

Synthesis and Antitumour Activity of New Derivatives of Flavone‐8‐acetic Acid (FAA). Part 1: 6-Methyl Derivatives

Abstract

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