Synthesis and reactivity of some 4-bromo- 2H-chromenes and 2H-thiochromenes

Christopher D. Gabbutt, David J. Hartley, John D. Hepworth, B. Mark Heron, Magan Kanjia, M. Moshfiqur Rahman

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

A facile synthesis of 4-bromo- 2H-chromenes and 2H-thiochromenes and of 1-bromo-3,4-dihydronaphthalene from the corresponding ketones and PBr3 is described. In some instances, significant quantities of the phosphonic acids (3) are isolated. Conversion of the bromo compounds to the lithio derivatives provides access to a wide range of novel 4-substituted 2H-chromenes and 2H-thiochromenes.

LanguageEnglish
Pages2507-2522
Number of pages16
JournalTetrahedron
Volume50
Issue number8
DOIs
Publication statusPublished - 21 Feb 1994
Externally publishedYes

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Phosphorous Acids
Ketones
Derivatives
5,7-dimethoxy-2-methyl-2H-benzopyran

Cite this

Gabbutt, Christopher D. ; Hartley, David J. ; Hepworth, John D. ; Heron, B. Mark ; Kanjia, Magan ; Rahman, M. Moshfiqur. / Synthesis and reactivity of some 4-bromo- 2H-chromenes and 2H-thiochromenes. In: Tetrahedron. 1994 ; Vol. 50, No. 8. pp. 2507-2522.
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Synthesis and reactivity of some 4-bromo- 2H-chromenes and 2H-thiochromenes. / Gabbutt, Christopher D.; Hartley, David J.; Hepworth, John D.; Heron, B. Mark; Kanjia, Magan; Rahman, M. Moshfiqur.

In: Tetrahedron, Vol. 50, No. 8, 21.02.1994, p. 2507-2522.

Research output: Contribution to journalArticle

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AU - Kanjia, Magan

AU - Rahman, M. Moshfiqur

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