Synthesis and reactivity of some 4-bromo- 2H-chromenes and 2H-thiochromenes

Christopher D. Gabbutt; David J. Hartley; John D. Hepworth; B. Mark Heron; Magan Kanjia; M. Moshfiqur Rahman

doi:10.1016/S0040-4020(01)86967-2

Synthesis and reactivity of some 4-bromo- 2H-chromenes and 2H-thiochromenes

Christopher D. Gabbutt, David J. Hartley, John D. Hepworth, B. Mark Heron, Magan Kanjia, M. Moshfiqur Rahman

University of Lancashire

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

A facile synthesis of 4-bromo- 2H-chromenes and 2H-thiochromenes and of 1-bromo-3,4-dihydronaphthalene from the corresponding ketones and PBr₃ is described. In some instances, significant quantities of the phosphonic acids (3) are isolated. Conversion of the bromo compounds to the lithio derivatives provides access to a wide range of novel 4-substituted 2H-chromenes and 2H-thiochromenes.

Original language	English
Pages (from-to)	2507-2522
Number of pages	16
Journal	Tetrahedron
Volume	50
Issue number	8
DOIs	https://doi.org/10.1016/S0040-4020(01)86967-2
Publication status	Published - 21 Feb 1994
Externally published	Yes

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title = "Synthesis and reactivity of some 4-bromo- 2H-chromenes and 2H-thiochromenes",

abstract = "A facile synthesis of 4-bromo- 2H-chromenes and 2H-thiochromenes and of 1-bromo-3,4-dihydronaphthalene from the corresponding ketones and PBr3 is described. In some instances, significant quantities of the phosphonic acids (3) are isolated. Conversion of the bromo compounds to the lithio derivatives provides access to a wide range of novel 4-substituted 2H-chromenes and 2H-thiochromenes.",

author = "Gabbutt, \{Christopher D.\} and Hartley, \{David J.\} and Hepworth, \{John D.\} and Heron, \{B. Mark\} and Magan Kanjia and Rahman, \{M. Moshfiqur\}",

year = "1994",

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doi = "10.1016/S0040-4020(01)86967-2",

language = "English",

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T1 - Synthesis and reactivity of some 4-bromo- 2H-chromenes and 2H-thiochromenes

AU - Gabbutt, Christopher D.

AU - Hartley, David J.

AU - Hepworth, John D.

AU - Heron, B. Mark

AU - Kanjia, Magan

AU - Rahman, M. Moshfiqur

PY - 1994/2/21

Y1 - 1994/2/21

N2 - A facile synthesis of 4-bromo- 2H-chromenes and 2H-thiochromenes and of 1-bromo-3,4-dihydronaphthalene from the corresponding ketones and PBr3 is described. In some instances, significant quantities of the phosphonic acids (3) are isolated. Conversion of the bromo compounds to the lithio derivatives provides access to a wide range of novel 4-substituted 2H-chromenes and 2H-thiochromenes.

AB - A facile synthesis of 4-bromo- 2H-chromenes and 2H-thiochromenes and of 1-bromo-3,4-dihydronaphthalene from the corresponding ketones and PBr3 is described. In some instances, significant quantities of the phosphonic acids (3) are isolated. Conversion of the bromo compounds to the lithio derivatives provides access to a wide range of novel 4-substituted 2H-chromenes and 2H-thiochromenes.

UR - https://www.scopus.com/pages/publications/0028085066

U2 - 10.1016/S0040-4020(01)86967-2

DO - 10.1016/S0040-4020(01)86967-2

M3 - Article

AN - SCOPUS:0028085066

SN - 0040-4020

VL - 50

SP - 2507

EP - 2522

JO - Tetrahedron

JF - Tetrahedron

IS - 8

ER -

Synthesis and reactivity of some 4-bromo- 2H-chromenes and 2H-thiochromenes

Abstract

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