Treatment of 2-aminothiazole (1) with triselenium dicyanide (2) afforded selenocyanate (3). Reduction of 3 with NaBH4 gave the diselenide 4. Compounds 3 and 4 were used as a key intermediate for the synthesis of a series of 2-amino-5-selenothiazoles. The newly synthesized compounds were evaluated as anti-inflammatory and analgesic agent.
|Number of pages||11|
|Journal||Phosphorus, Sulfur and Silicon and the Related Elements|
|Early online date||16 Oct 2014|
|Publication status||Published - 2 Nov 2014|