Synthesis, Anti-Inflammatory, and Analgesic Evaluation of Some 2-Amino-5-Selenothiazoles

Moustafa A. Gouda; Yousery El Sayed Sherif; Mohamed S. Elsherbini

doi:10.1080/10426507.2014.884091

Synthesis, Anti-Inflammatory, and Analgesic Evaluation of Some 2-Amino-5-Selenothiazoles

Moustafa A. Gouda, Yousery El Sayed Sherif, Mohamed S. Elsherbini

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Treatment of 2-aminothiazole (1) with triselenium dicyanide (2) afforded selenocyanate (3). Reduction of 3 with NaBH₄ gave the diselenide 4. Compounds 3 and 4 were used as a key intermediate for the synthesis of a series of 2-amino-5-selenothiazoles. The newly synthesized compounds were evaluated as anti-inflammatory and analgesic agent.

Original language	English
Pages (from-to)	1633-1643
Number of pages	11
Journal	Phosphorus, Sulfur and Silicon and the Related Elements
Volume	189
Issue number	11
Early online date	16 Oct 2014
DOIs	https://doi.org/10.1080/10426507.2014.884091
Publication status	Published - 2 Nov 2014
Externally published	Yes

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title = "Synthesis, Anti-Inflammatory, and Analgesic Evaluation of Some 2-Amino-5-Selenothiazoles",

abstract = "Treatment of 2-aminothiazole (1) with triselenium dicyanide (2) afforded selenocyanate (3). Reduction of 3 with NaBH4 gave the diselenide 4. Compounds 3 and 4 were used as a key intermediate for the synthesis of a series of 2-amino-5-selenothiazoles. The newly synthesized compounds were evaluated as anti-inflammatory and analgesic agent.",

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T1 - Synthesis, Anti-Inflammatory, and Analgesic Evaluation of Some 2-Amino-5-Selenothiazoles

AU - Gouda, Moustafa A.

AU - Sherif, Yousery El Sayed

AU - Elsherbini, Mohamed S.

PY - 2014/11/2

Y1 - 2014/11/2

N2 - Treatment of 2-aminothiazole (1) with triselenium dicyanide (2) afforded selenocyanate (3). Reduction of 3 with NaBH4 gave the diselenide 4. Compounds 3 and 4 were used as a key intermediate for the synthesis of a series of 2-amino-5-selenothiazoles. The newly synthesized compounds were evaluated as anti-inflammatory and analgesic agent.

AB - Treatment of 2-aminothiazole (1) with triselenium dicyanide (2) afforded selenocyanate (3). Reduction of 3 with NaBH4 gave the diselenide 4. Compounds 3 and 4 were used as a key intermediate for the synthesis of a series of 2-amino-5-selenothiazoles. The newly synthesized compounds were evaluated as anti-inflammatory and analgesic agent.

KW - 2-Amino-thiazole

KW - analgesic agent

KW - antiinflammatory

KW - coumarin

KW - naphthoquinone

KW - triselenium dicyanide

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U2 - 10.1080/10426507.2014.884091

DO - 10.1080/10426507.2014.884091

M3 - Article

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VL - 189

SP - 1633

EP - 1643

JO - Phosphorus, Sulfur and Silicon and the Related Elements

JF - Phosphorus, Sulfur and Silicon and the Related Elements

SN - 1042-6507

IS - 11

ER -

Synthesis, Anti-Inflammatory, and Analgesic Evaluation of Some 2-Amino-5-Selenothiazoles

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