Synthesis, Anti-Inflammatory, and Analgesic Evaluation of Some 2-Amino-5-Selenothiazoles

Moustafa A. Gouda, Yousery El Sayed Sherif, Mohamed S. Elsherbini

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Treatment of 2-aminothiazole (1) with triselenium dicyanide (2) afforded selenocyanate (3). Reduction of 3 with NaBH4 gave the diselenide 4. Compounds 3 and 4 were used as a key intermediate for the synthesis of a series of 2-amino-5-selenothiazoles. The newly synthesized compounds were evaluated as anti-inflammatory and analgesic agent.

Original languageEnglish
Pages (from-to)1633-1643
Number of pages11
JournalPhosphorus, Sulfur and Silicon and the Related Elements
Volume189
Issue number11
Early online date16 Oct 2014
DOIs
Publication statusPublished - 2 Nov 2014
Externally publishedYes

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