Synthesis, characterisation and biological properties of a silver helicate which displays enhanced activity towards methicillin-resistant Staphylococcus aureus (MRSA)

Peltine Ndifon; Emma C. Pinder; Christopher H.L. Slater; Christopher J. Clemett; Auska A.T. McRobbie; Samuel P. Rayner; Shalith Wickramarachchi; Karima Bertal-Ngaage; Simon J. Allison; Rebecca Dowey; Jane Harmer; Martin Carr; Anthony J. Slate; Roger M. Phillips; Jonathan A. Butler; Craig R. Rice; Martina Whitehead

doi:10.1039/d6dt00038j

Synthesis, characterisation and biological properties of a silver helicate which displays enhanced activity towards methicillin-resistant Staphylococcus aureus (MRSA)

Peltine Ndifon, Emma C. Pinder, Christopher H.L. Slater, Christopher J. Clemett, Auska A.T. McRobbie, Samuel P. Rayner, Shalith Wickramarachchi, Karima Bertal-Ngaage, Simon J. Allison, Rebecca Dowey, Jane Harmer, Martin Carr, Anthony J. Slate, Roger M. Phillips, Jonathan A. Butler, Craig R. Rice, Martina Whitehead

Manchester Metropolitan University

Research output: Contribution to journal › Article › peer-review

Abstract

Antimicrobial resistance is an ever growing concern and the development of novel treatment methods is urgently required. In this study a novel bis-bidentate ligand strand which forms a dinuclear double helicate in solution with silver cations, [Ag₂L₂]²⁺ demonstrated cytotoxicity against a range of cancer cell lines and antimicrobial activity against bacterial pathogens E. coli, P. aeruginosa and S. aureus (a methicillin resistant strain; MRSA), with the latter being at least 8 times more sensitive to the helicate complex compared to silver cations on their own.

Original language	English
Number of pages	5
Journal	Dalton Transactions
Early online date	18 Feb 2026
DOIs	https://doi.org/10.1039/d6dt00038j
Publication status	E-pub ahead of print - 18 Feb 2026

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10.1039/d6dt00038jLicence: CC BY

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Ndifon, P., Pinder, E. C., Slater, C. H. L., Clemett, C. J., McRobbie, A. A. T., Rayner, S. P., Wickramarachchi, S., Bertal-Ngaage, K., Allison, S. J., Dowey, R., Harmer, J., Carr, M., Slate, A. J., Phillips, R. M., Butler, J. A., Rice, C. R., & Whitehead, M. (2026). Synthesis, characterisation and biological properties of a silver helicate which displays enhanced activity towards methicillin-resistant Staphylococcus aureus (MRSA). Dalton Transactions. Advance online publication. https://doi.org/10.1039/d6dt00038j

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title = "Synthesis, characterisation and biological properties of a silver helicate which displays enhanced activity towards methicillin-resistant Staphylococcus aureus (MRSA)",

abstract = "Antimicrobial resistance is an ever growing concern and the development of novel treatment methods is urgently required. In this study a novel bis-bidentate ligand strand which forms a dinuclear double helicate in solution with silver cations, [Ag2L2]2+ demonstrated cytotoxicity against a range of cancer cell lines and antimicrobial activity against bacterial pathogens E. coli, P. aeruginosa and S. aureus (a methicillin resistant strain; MRSA), with the latter being at least 8 times more sensitive to the helicate complex compared to silver cations on their own.",

keywords = "Silver dinuclear double helicate, Antimicrobial activity against MRSA, Metallosupramolecular anticancer agents",

author = "Peltine Ndifon and Pinder, \{Emma C.\} and Slater, \{Christopher H.L.\} and Clemett, \{Christopher J.\} and McRobbie, \{Auska A.T.\} and Rayner, \{Samuel P.\} and Shalith Wickramarachchi and Karima Bertal-Ngaage and Allison, \{Simon J.\} and Rebecca Dowey and Jane Harmer and Martin Carr and Slate, \{Anthony J.\} and Phillips, \{Roger M.\} and Butler, \{Jonathan A.\} and Rice, \{Craig R.\} and Martina Whitehead",

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year = "2026",

month = feb,

day = "18",

doi = "10.1039/d6dt00038j",

language = "English",

journal = "Dalton Transactions",

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Ndifon, P, Pinder, EC, Slater, CHL , Clemett, CJ, McRobbie, AAT, Rayner, SP, Wickramarachchi, S, Bertal-Ngaage, K, Allison, SJ , Dowey, R , Harmer, J , Carr, M , Slate, AJ , Phillips, RM, Butler, JA, Rice, CR & Whitehead, M 2026, 'Synthesis, characterisation and biological properties of a silver helicate which displays enhanced activity towards methicillin-resistant Staphylococcus aureus (MRSA)', Dalton Transactions. https://doi.org/10.1039/d6dt00038j

TY - JOUR

T1 - Synthesis, characterisation and biological properties of a silver helicate which displays enhanced activity towards methicillin-resistant Staphylococcus aureus (MRSA)

AU - Ndifon, Peltine

AU - Pinder, Emma C.

AU - Slater, Christopher H.L.

AU - Clemett, Christopher J.

AU - McRobbie, Auska A.T.

AU - Rayner, Samuel P.

AU - Wickramarachchi, Shalith

AU - Bertal-Ngaage, Karima

AU - Allison, Simon J.

AU - Dowey, Rebecca

AU - Harmer, Jane

AU - Carr, Martin

AU - Slate, Anthony J.

AU - Phillips, Roger M.

AU - Butler, Jonathan A.

AU - Rice, Craig R.

AU - Whitehead, Martina

PY - 2026/2/18

Y1 - 2026/2/18

N2 - Antimicrobial resistance is an ever growing concern and the development of novel treatment methods is urgently required. In this study a novel bis-bidentate ligand strand which forms a dinuclear double helicate in solution with silver cations, [Ag2L2]2+ demonstrated cytotoxicity against a range of cancer cell lines and antimicrobial activity against bacterial pathogens E. coli, P. aeruginosa and S. aureus (a methicillin resistant strain; MRSA), with the latter being at least 8 times more sensitive to the helicate complex compared to silver cations on their own.

AB - Antimicrobial resistance is an ever growing concern and the development of novel treatment methods is urgently required. In this study a novel bis-bidentate ligand strand which forms a dinuclear double helicate in solution with silver cations, [Ag2L2]2+ demonstrated cytotoxicity against a range of cancer cell lines and antimicrobial activity against bacterial pathogens E. coli, P. aeruginosa and S. aureus (a methicillin resistant strain; MRSA), with the latter being at least 8 times more sensitive to the helicate complex compared to silver cations on their own.

KW - Silver dinuclear double helicate

KW - Antimicrobial activity against MRSA

KW - Metallosupramolecular anticancer agents

UR - https://www.scopus.com/pages/publications/105030349871

U2 - 10.1039/d6dt00038j

DO - 10.1039/d6dt00038j

M3 - Article

AN - SCOPUS:105030349871

SN - 1477-9226

JO - Dalton Transactions

JF - Dalton Transactions

ER -

Synthesis, characterisation and biological properties of a silver helicate which displays enhanced activity towards methicillin-resistant Staphylococcus aureus (MRSA)

Abstract

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