Synthesis, Characterization and Chemosensitivity Studies of Half-Sandwich Ruthenium, Rhodium and Iridium Complexes Containing к1 (S) and к2 (N,S) Aroylthiourea Ligands

Agreeda Lapasam, Omar Hussain, Roger M. Phillips, Werner Kaminsky, Mohan Rao Kollipara

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The reaction of [(p-cymene)RuCl2]2 and [Cp*MCl2]2 (M = Rh/Ir) metal precursors with aroylthiourea ligands (L1-L3) yielded a series of neutral mono-dentate complexes 1–9. The neutral mono-dentate coordination of aroylthiourea with metals via S atom was confirmed by single crystal X-ray diffraction study. Further reaction of mono-dentate complexes 1–9 with excess NaN3 in polar solvent resulted in the formation of highly strained four member ring к2 (N,S) azido complexes 10–18. Further these complexes were treated with activated alkynes to isolate triazole complexes, but unfortunately the reaction was unsuccessful. All these complexes were fully characterized by various spectroscopic techniques. The molecular structures of the representative complexes have been determined by single crystal X-ray diffraction studies. The molecular structures of the complexes revealed typical piano stool geometry around the metal center. The chemosensitivity activities of the complexes 1–9 evaluated against the cancer cell line HCT-116 (human colorectal carcinoma) and ARPE-19 (human retinal epithelial cells) cell line. Of these, complex 3 was the most potent and whilst its potency was less than cisplatin, its selectivity for cancer as opposed to non-cancer cell lines in vitro was comparable to cisplatin.

Original languageEnglish
Pages (from-to)272-280
Number of pages9
JournalJournal of Organometallic Chemistry
Volume880
Early online date19 Nov 2018
DOIs
Publication statusPublished - 1 Feb 2019

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Iridium
Rhodium
Ruthenium
iridium
rhodium
cultured cells
ruthenium
cancer
Metals
Ligands
Cells
Molecular Structure
Cell Line
X-Ray Diffraction
Molecular structure
Cisplatin
ligands
molecular structure
synthesis
Single crystals

Cite this

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title = "Synthesis, Characterization and Chemosensitivity Studies of Half-Sandwich Ruthenium, Rhodium and Iridium Complexes Containing к1 (S) and к2 (N,S) Aroylthiourea Ligands",
abstract = "The reaction of [(p-cymene)RuCl2]2 and [Cp*MCl2]2 (M = Rh/Ir) metal precursors with aroylthiourea ligands (L1-L3) yielded a series of neutral mono-dentate complexes 1–9. The neutral mono-dentate coordination of aroylthiourea with metals via S atom was confirmed by single crystal X-ray diffraction study. Further reaction of mono-dentate complexes 1–9 with excess NaN3 in polar solvent resulted in the formation of highly strained four member ring к2 (N,S) azido complexes 10–18. Further these complexes were treated with activated alkynes to isolate triazole complexes, but unfortunately the reaction was unsuccessful. All these complexes were fully characterized by various spectroscopic techniques. The molecular structures of the representative complexes have been determined by single crystal X-ray diffraction studies. The molecular structures of the complexes revealed typical piano stool geometry around the metal center. The chemosensitivity activities of the complexes 1–9 evaluated against the cancer cell line HCT-116 (human colorectal carcinoma) and ARPE-19 (human retinal epithelial cells) cell line. Of these, complex 3 was the most potent and whilst its potency was less than cisplatin, its selectivity for cancer as opposed to non-cancer cell lines in vitro was comparable to cisplatin.",
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year = "2019",
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Synthesis, Characterization and Chemosensitivity Studies of Half-Sandwich Ruthenium, Rhodium and Iridium Complexes Containing к1 (S) and к2 (N,S) Aroylthiourea Ligands. / Lapasam, Agreeda; Hussain, Omar; Phillips, Roger M.; Kaminsky, Werner; Kollipara, Mohan Rao.

In: Journal of Organometallic Chemistry, Vol. 880, 01.02.2019, p. 272-280.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synthesis, Characterization and Chemosensitivity Studies of Half-Sandwich Ruthenium, Rhodium and Iridium Complexes Containing к1 (S) and к2 (N,S) Aroylthiourea Ligands

AU - Lapasam, Agreeda

AU - Hussain, Omar

AU - Phillips, Roger M.

AU - Kaminsky, Werner

AU - Kollipara, Mohan Rao

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AB - The reaction of [(p-cymene)RuCl2]2 and [Cp*MCl2]2 (M = Rh/Ir) metal precursors with aroylthiourea ligands (L1-L3) yielded a series of neutral mono-dentate complexes 1–9. The neutral mono-dentate coordination of aroylthiourea with metals via S atom was confirmed by single crystal X-ray diffraction study. Further reaction of mono-dentate complexes 1–9 with excess NaN3 in polar solvent resulted in the formation of highly strained four member ring к2 (N,S) azido complexes 10–18. Further these complexes were treated with activated alkynes to isolate triazole complexes, but unfortunately the reaction was unsuccessful. All these complexes were fully characterized by various spectroscopic techniques. The molecular structures of the representative complexes have been determined by single crystal X-ray diffraction studies. The molecular structures of the complexes revealed typical piano stool geometry around the metal center. The chemosensitivity activities of the complexes 1–9 evaluated against the cancer cell line HCT-116 (human colorectal carcinoma) and ARPE-19 (human retinal epithelial cells) cell line. Of these, complex 3 was the most potent and whilst its potency was less than cisplatin, its selectivity for cancer as opposed to non-cancer cell lines in vitro was comparable to cisplatin.

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