Synthesis of Highly Substituted Pyrroles via Nucleophilic Catalysis

Simbarashe Ngwerume, Jason E. Camp

Research output: Contribution to journalArticlepeer-review

77 Citations (Scopus)


Figure presented. A nucleophilic catalysis method providing a concise synthesis of di-, tri-, and tetrasubstituted pyrroles is described. This regioselective one-pot method relies on nucleophilic catalysis of the intermolecular addition of oximes to activated alkynes and thermal rearrangement of the in situ generated O-vinyl oximes to form pyrroles that contain a functional group handle at the C3/C4 position.

Original languageEnglish
Pages (from-to)6271-6274
Number of pages4
JournalJournal of Organic Chemistry
Issue number18
Early online date18 Aug 2010
Publication statusPublished - 17 Sep 2010
Externally publishedYes


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