Synthesis of Highly Substituted Pyrroles via Nucleophilic Catalysis

Simbarashe Ngwerume, Jason E. Camp

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Figure presented. A nucleophilic catalysis method providing a concise synthesis of di-, tri-, and tetrasubstituted pyrroles is described. This regioselective one-pot method relies on nucleophilic catalysis of the intermolecular addition of oximes to activated alkynes and thermal rearrangement of the in situ generated O-vinyl oximes to form pyrroles that contain a functional group handle at the C3/C4 position.

LanguageEnglish
Pages6271-6274
Number of pages4
JournalJournal of Organic Chemistry
Volume75
Issue number18
Early online date18 Aug 2010
DOIs
Publication statusPublished - 17 Sep 2010
Externally publishedYes

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Pyrroles
Oximes
Catalysis
Alkynes
Functional groups
Hot Temperature

Cite this

Ngwerume, Simbarashe ; Camp, Jason E. / Synthesis of Highly Substituted Pyrroles via Nucleophilic Catalysis. In: Journal of Organic Chemistry. 2010 ; Vol. 75, No. 18. pp. 6271-6274.
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Synthesis of Highly Substituted Pyrroles via Nucleophilic Catalysis. / Ngwerume, Simbarashe; Camp, Jason E.

In: Journal of Organic Chemistry, Vol. 75, No. 18, 17.09.2010, p. 6271-6274.

Research output: Contribution to journalArticle

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