Synthesis of iridium and ruthenium complexes with (N,N), (N,O) and (O,O) coordinating bidentate ligands as potential anti-cancer agents

Stephanie J. Lucas; Rianne M. Lord; Rachel L. Wilson; Roger M. Phillips; Visuvanathar Sridharan; Patrick C. McGowan

doi:10.1039/c2dt32104a

Synthesis of iridium and ruthenium complexes with (N,N), (N,O) and (O,O) coordinating bidentate ligands as potential anti-cancer agents

Stephanie J. Lucas, Rianne M. Lord, Rachel L. Wilson, Roger M. Phillips, Visuvanathar Sridharan, Patrick C. McGowan

Research output: Contribution to journal › Article › peer-review

83 Citations (Scopus)

Abstract

Several Ru-arene and Ir-Cp* complexes have been prepared incorporating (N,N), (N,O) and (O,O) coordinating bidentate ligands and have been found to be active against both HT-29 and MCF-7 cell lines. By incorporating a biologically active ligand into a metal complex the anti-cancer activity is increased.

Original language	English
Pages (from-to)	13800-13802
Number of pages	3
Journal	Dalton Transactions
Volume	41
Issue number	45
Early online date	14 Sep 2012
DOIs	https://doi.org/10.1039/c2dt32104a
Publication status	Published - 7 Dec 2012
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1039/c2dt32104aLicence: Unspecified

Cite this

@article{4f68e1df3ed646f4b27771ad3424c094,

title = "Synthesis of iridium and ruthenium complexes with (N,N), (N,O) and (O,O) coordinating bidentate ligands as potential anti-cancer agents",

abstract = "Several Ru-arene and Ir-Cp* complexes have been prepared incorporating (N,N), (N,O) and (O,O) coordinating bidentate ligands and have been found to be active against both HT-29 and MCF-7 cell lines. By incorporating a biologically active ligand into a metal complex the anti-cancer activity is increased.",

author = "Lucas, {Stephanie J.} and Lord, {Rianne M.} and Wilson, {Rachel L.} and Phillips, {Roger M.} and Visuvanathar Sridharan and McGowan, {Patrick C.}",

year = "2012",

month = dec,

day = "7",

doi = "10.1039/c2dt32104a",

language = "English",

volume = "41",

pages = "13800--13802",

journal = "Dalton Transactions",

issn = "1477-9226",

publisher = "Royal Society of Chemistry",

number = "45",

}

TY - JOUR

T1 - Synthesis of iridium and ruthenium complexes with (N,N), (N,O) and (O,O) coordinating bidentate ligands as potential anti-cancer agents

AU - Lucas, Stephanie J.

AU - Lord, Rianne M.

AU - Wilson, Rachel L.

AU - Phillips, Roger M.

AU - Sridharan, Visuvanathar

AU - McGowan, Patrick C.

PY - 2012/12/7

Y1 - 2012/12/7

N2 - Several Ru-arene and Ir-Cp* complexes have been prepared incorporating (N,N), (N,O) and (O,O) coordinating bidentate ligands and have been found to be active against both HT-29 and MCF-7 cell lines. By incorporating a biologically active ligand into a metal complex the anti-cancer activity is increased.

AB - Several Ru-arene and Ir-Cp* complexes have been prepared incorporating (N,N), (N,O) and (O,O) coordinating bidentate ligands and have been found to be active against both HT-29 and MCF-7 cell lines. By incorporating a biologically active ligand into a metal complex the anti-cancer activity is increased.

UR - http://www.scopus.com/inward/record.url?scp=84868117273&partnerID=8YFLogxK

UR - http://pubs.rsc.org/en/journals/journal/dt

U2 - 10.1039/c2dt32104a

DO - 10.1039/c2dt32104a

M3 - Article

C2 - 23015068

AN - SCOPUS:84868117273

VL - 41

SP - 13800

EP - 13802

JO - Dalton Transactions

JF - Dalton Transactions

SN - 1477-9226

IS - 45

ER -

Synthesis of iridium and ruthenium complexes with (N,N), (N,O) and (O,O) coordinating bidentate ligands as potential anti-cancer agents

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this