Synthesis of iridium and ruthenium complexes with (N,N), (N,O) and (O,O) coordinating bidentate ligands as potential anti-cancer agents

Stephanie J. Lucas; Rianne M. Lord; Rachel L. Wilson; Roger M. Phillips; Visuvanathar Sridharan; Patrick C. McGowan

doi:10.1039/c2dt32104a

Synthesis of iridium and ruthenium complexes with (N,N), (N,O) and (O,O) coordinating bidentate ligands as potential anti-cancer agents

Stephanie J. Lucas, Rianne M. Lord, Rachel L. Wilson, Roger M. Phillips, Visuvanathar Sridharan, Patrick C. McGowan

Research output: Contribution to journal › Article › peer-review

72 Citations (Scopus)

Abstract

Several Ru-arene and Ir-Cp* complexes have been prepared incorporating (N,N), (N,O) and (O,O) coordinating bidentate ligands and have been found to be active against both HT-29 and MCF-7 cell lines. By incorporating a biologically active ligand into a metal complex the anti-cancer activity is increased.

Original language	English
Pages (from-to)	13800-13802
Number of pages	3
Journal	Dalton Transactions
Volume	41
Issue number	45
Early online date	14 Sep 2012
DOIs	https://doi.org/10.1039/c2dt32104a
Publication status	Published - 7 Dec 2012
Externally published	Yes

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title = "Synthesis of iridium and ruthenium complexes with (N,N), (N,O) and (O,O) coordinating bidentate ligands as potential anti-cancer agents",

abstract = "Several Ru-arene and Ir-Cp* complexes have been prepared incorporating (N,N), (N,O) and (O,O) coordinating bidentate ligands and have been found to be active against both HT-29 and MCF-7 cell lines. By incorporating a biologically active ligand into a metal complex the anti-cancer activity is increased.",

author = "Lucas, {Stephanie J.} and Lord, {Rianne M.} and Wilson, {Rachel L.} and Phillips, {Roger M.} and Visuvanathar Sridharan and McGowan, {Patrick C.}",

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Synthesis of iridium and ruthenium complexes with (N,N), (N,O) and (O,O) coordinating bidentate ligands as potential anti-cancer agents. / Lucas, Stephanie J.; Lord, Rianne M.; Wilson, Rachel L.; Phillips, Roger M.; Sridharan, Visuvanathar; McGowan, Patrick C.

In: Dalton Transactions, Vol. 41, No. 45, 07.12.2012, p. 13800-13802.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis of iridium and ruthenium complexes with (N,N), (N,O) and (O,O) coordinating bidentate ligands as potential anti-cancer agents

AU - Lucas, Stephanie J.

AU - Lord, Rianne M.

AU - Wilson, Rachel L.

AU - Phillips, Roger M.

AU - Sridharan, Visuvanathar

AU - McGowan, Patrick C.

PY - 2012/12/7

Y1 - 2012/12/7

N2 - Several Ru-arene and Ir-Cp* complexes have been prepared incorporating (N,N), (N,O) and (O,O) coordinating bidentate ligands and have been found to be active against both HT-29 and MCF-7 cell lines. By incorporating a biologically active ligand into a metal complex the anti-cancer activity is increased.

AB - Several Ru-arene and Ir-Cp* complexes have been prepared incorporating (N,N), (N,O) and (O,O) coordinating bidentate ligands and have been found to be active against both HT-29 and MCF-7 cell lines. By incorporating a biologically active ligand into a metal complex the anti-cancer activity is increased.

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SN - 1477-9226

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Synthesis of iridium and ruthenium complexes with (N,N), (N,O) and (O,O) coordinating bidentate ligands as potential anti-cancer agents

Abstract

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