Synthesis of ureas in the bio-alternative solvent Cyrene

Liam Mistry, Kopano Mapesa, Thomas W. Bousfield, Jason E. Camp

Research output: Contribution to journalArticle

27 Citations (Scopus)


Cyrene as a bio-alternative solvent: a highly efficient, waste minimizing protocol for the synthesis of ureas from isocyanates and secondary amines in the bio-available solvent Cyrene is reported. This method eliminated the use of toxic solvents, such as DMF, and established a simple work-up procedure for removal of the Cyrene, which led to a 28-fold increase in molar efficiency versus industrial standard protocols.

Original languageEnglish
Pages (from-to)2123-2128
Number of pages6
JournalGreen Chemistry
Issue number9
Publication statusPublished - 24 Apr 2017

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    Mistry, L., Mapesa, K., Bousfield, T. W., & Camp, J. E. (2017). Synthesis of ureas in the bio-alternative solvent Cyrene. Green Chemistry, 19(9), 2123-2128.