Synthesis of ureas in the bio-alternative solvent Cyrene

Liam Mistry, Kopano Mapesa, Thomas W. Bousfield, Jason E. Camp

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Cyrene as a bio-alternative solvent: a highly efficient, waste minimizing protocol for the synthesis of ureas from isocyanates and secondary amines in the bio-available solvent Cyrene is reported. This method eliminated the use of toxic solvents, such as DMF, and established a simple work-up procedure for removal of the Cyrene, which led to a 28-fold increase in molar efficiency versus industrial standard protocols.

Original languageEnglish
Pages (from-to)2123-2128
Number of pages6
JournalGreen Chemistry
Volume19
Issue number9
DOIs
Publication statusPublished - 24 Apr 2017

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Urea
urea
Isocyanates
Poisons
Amines
fold
protocol
amine
method
removal

Cite this

Mistry, L., Mapesa, K., Bousfield, T. W., & Camp, J. E. (2017). Synthesis of ureas in the bio-alternative solvent Cyrene. Green Chemistry, 19(9), 2123-2128. https://doi.org/10.1039/c7gc00908a
Mistry, Liam ; Mapesa, Kopano ; Bousfield, Thomas W. ; Camp, Jason E. / Synthesis of ureas in the bio-alternative solvent Cyrene. In: Green Chemistry. 2017 ; Vol. 19, No. 9. pp. 2123-2128.
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Mistry, L, Mapesa, K, Bousfield, TW & Camp, JE 2017, 'Synthesis of ureas in the bio-alternative solvent Cyrene', Green Chemistry, vol. 19, no. 9, pp. 2123-2128. https://doi.org/10.1039/c7gc00908a

Synthesis of ureas in the bio-alternative solvent Cyrene. / Mistry, Liam; Mapesa, Kopano; Bousfield, Thomas W.; Camp, Jason E.

In: Green Chemistry, Vol. 19, No. 9, 24.04.2017, p. 2123-2128.

Research output: Contribution to journalArticle

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Mistry L, Mapesa K, Bousfield TW, Camp JE. Synthesis of ureas in the bio-alternative solvent Cyrene. Green Chemistry. 2017 Apr 24;19(9):2123-2128. https://doi.org/10.1039/c7gc00908a