Synthesis of ureas in the bio-alternative solvent Cyrene

Liam Mistry; Kopano Mapesa; Thomas W. Bousfield; Jason E. Camp

doi:10.1039/c7gc00908a

Synthesis of ureas in the bio-alternative solvent Cyrene

Liam Mistry, Kopano Mapesa, Thomas W. Bousfield, Jason E. Camp

Research output: Contribution to journal › Article › peer-review

86 Citations (Scopus)

Abstract

Cyrene as a bio-alternative solvent: a highly efficient, waste minimizing protocol for the synthesis of ureas from isocyanates and secondary amines in the bio-available solvent Cyrene is reported. This method eliminated the use of toxic solvents, such as DMF, and established a simple work-up procedure for removal of the Cyrene, which led to a 28-fold increase in molar efficiency versus industrial standard protocols.

Original language	English
Pages (from-to)	2123-2128
Number of pages	6
Journal	Green Chemistry
Volume	19
Issue number	9
Early online date	24 Apr 2017
DOIs	https://doi.org/10.1039/c7gc00908a
Publication status	Published - 7 May 2017

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10.1039/c7gc00908a

http://eprints.hud.ac.uk/id/eprint/31795/

Cite this

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AB - Cyrene as a bio-alternative solvent: a highly efficient, waste minimizing protocol for the synthesis of ureas from isocyanates and secondary amines in the bio-available solvent Cyrene is reported. This method eliminated the use of toxic solvents, such as DMF, and established a simple work-up procedure for removal of the Cyrene, which led to a 28-fold increase in molar efficiency versus industrial standard protocols.

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Synthesis of ureas in the bio-alternative solvent Cyrene

Abstract

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