Synthesis, structural and in-vitro functional studies of half-sandwich platinum group metal complexes having various bonding modes of benzhydrazone derivative ligands

Lathewdeipor Shadap, Jaya Lakshmi Tyagi, Krishna Mohan Poluri, Emma Pinder, Roger Phillips, Werner Kaminsky, Mohan Rao Kollipara

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Complexes 1–9 were synthesized by reacting metal precursors [(arene)MCl 2] 2 (arene = p-cymene, Cp*; M = Ru, Rh and Ir) and benzhydrazone derivative ligands L1, L2 and L3 which resulted in the formation of cationic complexes with PF 6 as the counter ion. Ruthenium complexes exhibited N∩O bonding mode while rhodium and iridium complexes exhibited N∩N bonding mode with the migration of the N–H proton to the adjacent C[dbnd]O (keto) group forming enol. Anti-bacterial activity studies (against Gram-positive and Gram-negative bacteria) as well as anti-cancer [HCT116 p53 wild type (p53 +/+) and HCT116 p53 null (p53 −/−)] were carried out for all the complexes as well as ligands where interestingly, ligand L2 and complex 5 showed high activity potency (in-vitro) for both biological studies. Amongst Ru, Rh and Ir, rhodium complexes showed more anticancer activity.

Original languageEnglish
Article number114293
Number of pages10
Early online date16 Dec 2019
Publication statusPublished - 15 Jan 2020


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