TY - JOUR
T1 - Synthesis, structural and in-vitro functional studies of half-sandwich platinum group metal complexes having various bonding modes of benzhydrazone derivative ligands
AU - Shadap, Lathewdeipor
AU - Tyagi, Jaya Lakshmi
AU - Poluri, Krishna Mohan
AU - Pinder, Emma
AU - Phillips, Roger
AU - Kaminsky, Werner
AU - Kollipara, Mohan Rao
PY - 2020/1/15
Y1 - 2020/1/15
N2 - Complexes 1–9 were synthesized by reacting metal precursors [(arene)MCl
2]
2 (arene = p-cymene, Cp*; M = Ru, Rh and Ir) and benzhydrazone derivative ligands L1, L2 and L3 which resulted in the formation of cationic complexes with PF
6 as the counter ion. Ruthenium complexes exhibited N∩O bonding mode while rhodium and iridium complexes exhibited N∩N bonding mode with the migration of the N–H proton to the adjacent C[dbnd]O (keto) group forming enol. Anti-bacterial activity studies (against Gram-positive and Gram-negative bacteria) as well as anti-cancer [HCT116 p53 wild type (p53
+/+) and HCT116 p53 null (p53
−/−)] were carried out for all the complexes as well as ligands where interestingly, ligand L2 and complex 5 showed high activity potency (in-vitro) for both biological studies. Amongst Ru, Rh and Ir, rhodium complexes showed more anticancer activity.
AB - Complexes 1–9 were synthesized by reacting metal precursors [(arene)MCl
2]
2 (arene = p-cymene, Cp*; M = Ru, Rh and Ir) and benzhydrazone derivative ligands L1, L2 and L3 which resulted in the formation of cationic complexes with PF
6 as the counter ion. Ruthenium complexes exhibited N∩O bonding mode while rhodium and iridium complexes exhibited N∩N bonding mode with the migration of the N–H proton to the adjacent C[dbnd]O (keto) group forming enol. Anti-bacterial activity studies (against Gram-positive and Gram-negative bacteria) as well as anti-cancer [HCT116 p53 wild type (p53
+/+) and HCT116 p53 null (p53
−/−)] were carried out for all the complexes as well as ligands where interestingly, ligand L2 and complex 5 showed high activity potency (in-vitro) for both biological studies. Amongst Ru, Rh and Ir, rhodium complexes showed more anticancer activity.
KW - Ruthenium
KW - rhodium
KW - iridium
KW - benzhydrazone
KW - in-vitro studies
UR - http://www.scopus.com/inward/record.url?scp=85076788815&partnerID=8YFLogxK
U2 - 10.1016/j.poly.2019.114293
DO - 10.1016/j.poly.2019.114293
M3 - Article
VL - 176
JO - Polyhedron
JF - Polyhedron
SN - 0277-5387
M1 - 114293
ER -
