Synthesis, structural and in-vitro functional studies of half-sandwich platinum group metal complexes having various bonding modes of benzhydrazone derivative ligands

Lathewdeipor Shadap, Jaya Lakshmi Tyagi, Krishna Mohan Poluri, Emma Pinder, Roger Phillips, Werner Kaminsky, Mohan Rao Kollipara

Research output: Contribution to journalArticle

Abstract

Complexes 1–9 were synthesized by reacting metal precursors [(arene)MCl 2] 2 (arene = p-cymene, Cp*; M = Ru, Rh and Ir) and benzhydrazone derivative ligands L1, L2 and L3 which resulted in the formation of cationic complexes with PF 6 as the counter ion. Ruthenium complexes exhibited N∩O bonding mode while rhodium and iridium complexes exhibited N∩N bonding mode with the migration of the N–H proton to the adjacent C[dbnd]O (keto) group forming enol. Anti-bacterial activity studies (against Gram-positive and Gram-negative bacteria) as well as anti-cancer [HCT116 p53 wild type (p53 +/+) and HCT116 p53 null (p53 −/−)] were carried out for all the complexes as well as ligands where interestingly, ligand L2 and complex 5 showed high activity potency (in-vitro) for both biological studies. Amongst Ru, Rh and Ir, rhodium complexes showed more anticancer activity.

Original languageEnglish
Article number114293
Number of pages10
JournalPolyhedron
Volume176
Early online date16 Dec 2019
DOIs
Publication statusPublished - 15 Jan 2020

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Coordination Complexes
Metal complexes
Platinum
Rhodium
platinum
Ligands
Derivatives
rhodium
ligands
synthesis
metals
Iridium
Radiation counters
Ruthenium
iridium
bacteria
ruthenium
Protons
Bacteria
counters

Cite this

Shadap, Lathewdeipor ; Tyagi, Jaya Lakshmi ; Poluri, Krishna Mohan ; Pinder, Emma ; Phillips, Roger ; Kaminsky, Werner ; Kollipara, Mohan Rao. / Synthesis, structural and in-vitro functional studies of half-sandwich platinum group metal complexes having various bonding modes of benzhydrazone derivative ligands. In: Polyhedron. 2020 ; Vol. 176.
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Synthesis, structural and in-vitro functional studies of half-sandwich platinum group metal complexes having various bonding modes of benzhydrazone derivative ligands. / Shadap, Lathewdeipor; Tyagi, Jaya Lakshmi; Poluri, Krishna Mohan; Pinder, Emma; Phillips, Roger; Kaminsky, Werner; Kollipara, Mohan Rao.

In: Polyhedron, Vol. 176, 114293, 15.01.2020.

Research output: Contribution to journalArticle

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AU - Shadap, Lathewdeipor

AU - Tyagi, Jaya Lakshmi

AU - Poluri, Krishna Mohan

AU - Pinder, Emma

AU - Phillips, Roger

AU - Kaminsky, Werner

AU - Kollipara, Mohan Rao

PY - 2020/1/15

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AB - Complexes 1–9 were synthesized by reacting metal precursors [(arene)MCl 2] 2 (arene = p-cymene, Cp*; M = Ru, Rh and Ir) and benzhydrazone derivative ligands L1, L2 and L3 which resulted in the formation of cationic complexes with PF 6 as the counter ion. Ruthenium complexes exhibited N∩O bonding mode while rhodium and iridium complexes exhibited N∩N bonding mode with the migration of the N–H proton to the adjacent C[dbnd]O (keto) group forming enol. Anti-bacterial activity studies (against Gram-positive and Gram-negative bacteria) as well as anti-cancer [HCT116 p53 wild type (p53 +/+) and HCT116 p53 null (p53 −/−)] were carried out for all the complexes as well as ligands where interestingly, ligand L2 and complex 5 showed high activity potency (in-vitro) for both biological studies. Amongst Ru, Rh and Ir, rhodium complexes showed more anticancer activity.

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KW - rhodium

KW - iridium

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