Synthesis, structural and in-vitro functional studies of half-sandwich platinum group metal complexes having various bonding modes of benzhydrazone derivative ligands

Lathewdeipor Shadap; Jaya Lakshmi Tyagi; Krishna Mohan Poluri; Emma Pinder; Roger Phillips; Werner Kaminsky; Mohan Rao Kollipara

doi:10.1016/j.poly.2019.114293

Synthesis, structural and in-vitro functional studies of half-sandwich platinum group metal complexes having various bonding modes of benzhydrazone derivative ligands

Lathewdeipor Shadap, Jaya Lakshmi Tyagi, Krishna Mohan Poluri, Emma Pinder, Roger Phillips, Werner Kaminsky, Mohan Rao Kollipara

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Complexes 1–9 were synthesized by reacting metal precursors [(arene)MCl ₂] ₂ (arene = p-cymene, Cp*; M = Ru, Rh and Ir) and benzhydrazone derivative ligands L1, L2 and L3 which resulted in the formation of cationic complexes with PF ₆ as the counter ion. Ruthenium complexes exhibited N∩O bonding mode while rhodium and iridium complexes exhibited N∩N bonding mode with the migration of the N–H proton to the adjacent C[dbnd]O (keto) group forming enol. Anti-bacterial activity studies (against Gram-positive and Gram-negative bacteria) as well as anti-cancer [HCT116 p53 wild type (p53 ^+/+) and HCT116 p53 null (p53 ^−/−)] were carried out for all the complexes as well as ligands where interestingly, ligand L2 and complex 5 showed high activity potency (in-vitro) for both biological studies. Amongst Ru, Rh and Ir, rhodium complexes showed more anticancer activity.

Original language	English
Article number	114293
Number of pages	10
Journal	Polyhedron
Volume	176
Early online date	16 Dec 2019
DOIs	https://doi.org/10.1016/j.poly.2019.114293
Publication status	Published - 15 Jan 2020

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title = "Synthesis, structural and in-vitro functional studies of half-sandwich platinum group metal complexes having various bonding modes of benzhydrazone derivative ligands",

abstract = "Complexes 1–9 were synthesized by reacting metal precursors [(arene)MCl 2] 2 (arene = p-cymene, Cp*; M = Ru, Rh and Ir) and benzhydrazone derivative ligands L1, L2 and L3 which resulted in the formation of cationic complexes with PF 6 as the counter ion. Ruthenium complexes exhibited N∩O bonding mode while rhodium and iridium complexes exhibited N∩N bonding mode with the migration of the N–H proton to the adjacent C[dbnd]O (keto) group forming enol. Anti-bacterial activity studies (against Gram-positive and Gram-negative bacteria) as well as anti-cancer [HCT116 p53 wild type (p53 +/+) and HCT116 p53 null (p53 −/−)] were carried out for all the complexes as well as ligands where interestingly, ligand L2 and complex 5 showed high activity potency (in-vitro) for both biological studies. Amongst Ru, Rh and Ir, rhodium complexes showed more anticancer activity. ",

keywords = "Ruthenium, rhodium, iridium, benzhydrazone, in-vitro studies",

author = "Lathewdeipor Shadap and Tyagi, \{Jaya Lakshmi\} and Poluri, \{Krishna Mohan\} and Emma Pinder and Roger Phillips and Werner Kaminsky and Kollipara, \{Mohan Rao\}",

year = "2020",

month = jan,

day = "15",

doi = "10.1016/j.poly.2019.114293",

language = "English",

volume = "176",

journal = "Polyhedron",

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TY - JOUR

T1 - Synthesis, structural and in-vitro functional studies of half-sandwich platinum group metal complexes having various bonding modes of benzhydrazone derivative ligands

AU - Shadap, Lathewdeipor

AU - Tyagi, Jaya Lakshmi

AU - Poluri, Krishna Mohan

AU - Pinder, Emma

AU - Phillips, Roger

AU - Kaminsky, Werner

AU - Kollipara, Mohan Rao

PY - 2020/1/15

Y1 - 2020/1/15

N2 - Complexes 1–9 were synthesized by reacting metal precursors [(arene)MCl 2] 2 (arene = p-cymene, Cp*; M = Ru, Rh and Ir) and benzhydrazone derivative ligands L1, L2 and L3 which resulted in the formation of cationic complexes with PF 6 as the counter ion. Ruthenium complexes exhibited N∩O bonding mode while rhodium and iridium complexes exhibited N∩N bonding mode with the migration of the N–H proton to the adjacent C[dbnd]O (keto) group forming enol. Anti-bacterial activity studies (against Gram-positive and Gram-negative bacteria) as well as anti-cancer [HCT116 p53 wild type (p53 +/+) and HCT116 p53 null (p53 −/−)] were carried out for all the complexes as well as ligands where interestingly, ligand L2 and complex 5 showed high activity potency (in-vitro) for both biological studies. Amongst Ru, Rh and Ir, rhodium complexes showed more anticancer activity.

AB - Complexes 1–9 were synthesized by reacting metal precursors [(arene)MCl 2] 2 (arene = p-cymene, Cp*; M = Ru, Rh and Ir) and benzhydrazone derivative ligands L1, L2 and L3 which resulted in the formation of cationic complexes with PF 6 as the counter ion. Ruthenium complexes exhibited N∩O bonding mode while rhodium and iridium complexes exhibited N∩N bonding mode with the migration of the N–H proton to the adjacent C[dbnd]O (keto) group forming enol. Anti-bacterial activity studies (against Gram-positive and Gram-negative bacteria) as well as anti-cancer [HCT116 p53 wild type (p53 +/+) and HCT116 p53 null (p53 −/−)] were carried out for all the complexes as well as ligands where interestingly, ligand L2 and complex 5 showed high activity potency (in-vitro) for both biological studies. Amongst Ru, Rh and Ir, rhodium complexes showed more anticancer activity.

KW - Ruthenium

KW - rhodium

KW - iridium

KW - benzhydrazone

KW - in-vitro studies

UR - https://www.scopus.com/pages/publications/85076788815

U2 - 10.1016/j.poly.2019.114293

DO - 10.1016/j.poly.2019.114293

M3 - Article

SN - 0277-5387

VL - 176

JO - Polyhedron

JF - Polyhedron

M1 - 114293

ER -

Synthesis, structural and in-vitro functional studies of half-sandwich platinum group metal complexes having various bonding modes of benzhydrazone derivative ligands

Abstract

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