Synthesis, structure and bonding modes of pyrazine based ligands of Cp*Rh and Cp*Ir complexes: The study of in-vitro cytotoxicity against human cell lines

Agreeda Lapasam, Emma Pinder, Roger M. Phillips, Werner Kaminsky, Mohan Rao Kollipara

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Abstract

The reaction of multidentate pyrazine based ligands was explored towards Cp*rhodium and Cp*iridium precursors. Mononuclear and dinuclear complexes formed by the ratio-based reaction between ligand and metal precursor. The representative complexes have been determined by single crystal X-ray diffraction studies. Cytotoxicity study of the ligands and their complexes are evaluated against human colorectal cancer cell lines HT-29, HCT-116 p53+/+ and HCT-116 p53−/− and ARPE-19 (non-cancer retinal epithelium) cells. Complexes 2-5 and 7-8 were cytotoxic to cells and although the potency of these complexes was less than cisplatin, selectivity towards cancer cell lines as opposed to non-cancer ARPE-19 cells was comparable to cisplatin. From in-vitro cytotoxicity studies complexes 4 and 5 demonstrated good selectivity towards HCT116 p53−/− cells suggesting that these complexes are promising leads for the treatment of p53 deficient cancers.
Original languageEnglish
Article number120887
JournalJournal of Organometallic Chemistry
Volume899
Early online date8 Aug 2019
DOIs
Publication statusPublished - 30 Oct 2019

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