Synthetic approaches to 1,2,5-benzothiadiazepine 1,1-dioxides - sulfonamide analogues of the 1,4-benzodiazepines

Karl Hemming, Christina Loukou

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Synthetic approaches to the 1,2,5-benzothiadiazepine 1,1-dioxides, sulfonamide analogues of the 1,4-benzodiazepines, are reviewed. The review incorporates the synthesis of bicyclic, tricyclic and tetracyclic systems, and includes approaches to sulfonamide analogues of the antitumour pyrrolobenzodiazepines, sulfonamide analogues of the tricyclic non-nucleosidic reverse transcriptase inhibiting benzodiazepines (such as nevirapine), and other systems of biological interest. Details of the reactions and biological activity of the 1,2,5-benzothiadiazepines are also given.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalJournal of Chemical Research
Volume2005
Issue number1
DOIs
Publication statusPublished - 1 Jan 2005

Fingerprint

Sulfonamides
Nevirapine
RNA-Directed DNA Polymerase
Bioactivity
Benzodiazepines
Bz-423

Cite this

@article{66ea653d7ec549ad9e6911da8a290bcc,
title = "Synthetic approaches to 1,2,5-benzothiadiazepine 1,1-dioxides - sulfonamide analogues of the 1,4-benzodiazepines",
abstract = "Synthetic approaches to the 1,2,5-benzothiadiazepine 1,1-dioxides, sulfonamide analogues of the 1,4-benzodiazepines, are reviewed. The review incorporates the synthesis of bicyclic, tricyclic and tetracyclic systems, and includes approaches to sulfonamide analogues of the antitumour pyrrolobenzodiazepines, sulfonamide analogues of the tricyclic non-nucleosidic reverse transcriptase inhibiting benzodiazepines (such as nevirapine), and other systems of biological interest. Details of the reactions and biological activity of the 1,2,5-benzothiadiazepines are also given.",
keywords = "1,4-benzodiazepine, Benzothiadiazepine, Pyrrolobenzodiazepine, Pyrrolobenzothiadiazepine, Sulfonamide",
author = "Karl Hemming and Christina Loukou",
year = "2005",
month = "1",
day = "1",
doi = "10.3184/0308234053431013",
language = "English",
volume = "2005",
pages = "1--12",
journal = "Journal of Chemical Research - Part S",
issn = "0308-2342",
publisher = "Science Reviews Ltd",
number = "1",

}

Synthetic approaches to 1,2,5-benzothiadiazepine 1,1-dioxides - sulfonamide analogues of the 1,4-benzodiazepines. / Hemming, Karl; Loukou, Christina.

In: Journal of Chemical Research, Vol. 2005, No. 1, 01.01.2005, p. 1-12.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Synthetic approaches to 1,2,5-benzothiadiazepine 1,1-dioxides - sulfonamide analogues of the 1,4-benzodiazepines

AU - Hemming, Karl

AU - Loukou, Christina

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Synthetic approaches to the 1,2,5-benzothiadiazepine 1,1-dioxides, sulfonamide analogues of the 1,4-benzodiazepines, are reviewed. The review incorporates the synthesis of bicyclic, tricyclic and tetracyclic systems, and includes approaches to sulfonamide analogues of the antitumour pyrrolobenzodiazepines, sulfonamide analogues of the tricyclic non-nucleosidic reverse transcriptase inhibiting benzodiazepines (such as nevirapine), and other systems of biological interest. Details of the reactions and biological activity of the 1,2,5-benzothiadiazepines are also given.

AB - Synthetic approaches to the 1,2,5-benzothiadiazepine 1,1-dioxides, sulfonamide analogues of the 1,4-benzodiazepines, are reviewed. The review incorporates the synthesis of bicyclic, tricyclic and tetracyclic systems, and includes approaches to sulfonamide analogues of the antitumour pyrrolobenzodiazepines, sulfonamide analogues of the tricyclic non-nucleosidic reverse transcriptase inhibiting benzodiazepines (such as nevirapine), and other systems of biological interest. Details of the reactions and biological activity of the 1,2,5-benzothiadiazepines are also given.

KW - 1,4-benzodiazepine

KW - Benzothiadiazepine

KW - Pyrrolobenzodiazepine

KW - Pyrrolobenzothiadiazepine

KW - Sulfonamide

UR - http://www.scopus.com/inward/record.url?scp=17144408303&partnerID=8YFLogxK

U2 - 10.3184/0308234053431013

DO - 10.3184/0308234053431013

M3 - Review article

VL - 2005

SP - 1

EP - 12

JO - Journal of Chemical Research - Part S

JF - Journal of Chemical Research - Part S

SN - 0308-2342

IS - 1

ER -