Synthetic approaches to 1,2,5-benzothiadiazepine 1,1-dioxides - sulfonamide analogues of the 1,4-benzodiazepines

Karl Hemming, Christina Loukou

Research output: Contribution to journalReview article

6 Citations (Scopus)


Synthetic approaches to the 1,2,5-benzothiadiazepine 1,1-dioxides, sulfonamide analogues of the 1,4-benzodiazepines, are reviewed. The review incorporates the synthesis of bicyclic, tricyclic and tetracyclic systems, and includes approaches to sulfonamide analogues of the antitumour pyrrolobenzodiazepines, sulfonamide analogues of the tricyclic non-nucleosidic reverse transcriptase inhibiting benzodiazepines (such as nevirapine), and other systems of biological interest. Details of the reactions and biological activity of the 1,2,5-benzothiadiazepines are also given.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalJournal of Chemical Research
Issue number1
Publication statusPublished - 1 Jan 2005


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