Synthetic Studies on Psychotrimine: Palladium-Catalysed Arylation of 2-(N -Indolyl) Amides

Emma L. Watson, Anthony Ball, Steven A. Raw, Stephen P. Marsden

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Through careful choice of conditions, 2-(N-indolyl) amides can be directed to undergo selectively either enolate arylation to give oxindoles or direct arylation to give indolo-fused benzodiazepines. The former chemistry facilitates the synthesis of the hexahydropyrrolindole core of psychotrimine.
LanguageEnglish
Pages146-150
Number of pages5
JournalSynlett
Volume27
Issue number1
Early online date9 Nov 2015
DOIs
Publication statusPublished - 4 Jan 2016
Externally publishedYes

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Palladium
Benzodiazepines
Amides
psychotrimine
oxindole

Cite this

Watson, Emma L. ; Ball, Anthony ; Raw, Steven A. ; Marsden, Stephen P. / Synthetic Studies on Psychotrimine : Palladium-Catalysed Arylation of 2-(N -Indolyl) Amides. In: Synlett. 2016 ; Vol. 27, No. 1. pp. 146-150.
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Synthetic Studies on Psychotrimine : Palladium-Catalysed Arylation of 2-(N -Indolyl) Amides. / Watson, Emma L.; Ball, Anthony; Raw, Steven A.; Marsden, Stephen P.

In: Synlett, Vol. 27, No. 1, 04.01.2016, p. 146-150.

Research output: Contribution to journalArticle

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