Tethered N-Heterocyclic Carbene-Carboranyl Silver Complexes for Cancer Therapy

Jordan Holmes, Rachel J. Kearsey, Katie A. Paske, Frances N. Singer, Suliman Atallah, Christopher M. Pask, Roger M. Phillips, Charlotte E. Willans

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Silver complexes of tethered N-heterocyclic carbene-carboranyl ligands have been prepared and fully characterized. The first example of silver bonded directly to the cage of o-carborane has been identified in the solid state. The presence of a carboranyl N substituent on the N-heterocyclic carbene significantly enhances the in vitro cytotoxicity of the silver complex against HCT116 p53+/+ and HCT116 p53-/- colon cancer cells in comparison to a phenyl derivative. Conversely, the presence of a carboranyl on the backbone of a xanthine-derived N-heterocyclic carbene decreases the in vitro cytotoxicity of the silver complex in comparison to its phenyl derivative. Stability studies on the xanthine-derived ligands and complexes show that decomposition via deboronation occurs in hydrous dimethyl sulfoxide, which may attribute to the contrasting in vitro behaviors of the carborane-containing complexes.

Original languageEnglish
Pages (from-to)2530-2538
Number of pages9
JournalOrganometallics
Volume38
Issue number12
DOIs
Publication statusPublished - 7 Jun 2019

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