TY - JOUR
T1 - The adenomatous polyposis coli tumor suppressor protein and microtubule dynamics
AU - Brüning-Richardson, Anke
AU - Morrison, Ewan E.
PY - 2007/5/1
Y1 - 2007/5/1
N2 - Colorectal cancer is closely associated with mutation of the gene encoding the adenomatous polyposis coli (APC) tumor suppressor protein. A role has been defined for APC in the Wnt signaling pathway, in which it is responsible for mediating the degradation of the protein β-catenin. This function is clearly responsible for the tumor suppressor activity of APC. However, other APC functions have been identified, notably involving the cytoskeleton, the loss of which may be involved in shaping the phenotype or contributing to the progression of colorectal cancer. Here we provide an insight into recent developments in the study of APC interactions with cytoskeletal elements.
AB - Colorectal cancer is closely associated with mutation of the gene encoding the adenomatous polyposis coli (APC) tumor suppressor protein. A role has been defined for APC in the Wnt signaling pathway, in which it is responsible for mediating the degradation of the protein β-catenin. This function is clearly responsible for the tumor suppressor activity of APC. However, other APC functions have been identified, notably involving the cytoskeleton, the loss of which may be involved in shaping the phenotype or contributing to the progression of colorectal cancer. Here we provide an insight into recent developments in the study of APC interactions with cytoskeletal elements.
KW - Adenomatous Polyposis Coli
KW - Tumor Suppressor Protein
KW - Adenomatous Polyposis Coli Gene
KW - Adenomatous Polyposis Coli Protein
KW - Colorectal Tumor Cell
UR - http://www.scopus.com/inward/record.url?scp=84855776196&partnerID=8YFLogxK
U2 - 10.1007/s11888-007-0005-7
DO - 10.1007/s11888-007-0005-7
M3 - Article
AN - SCOPUS:84855776196
VL - 3
SP - 82
EP - 86
JO - Current Colorectal Cancer Reports
JF - Current Colorectal Cancer Reports
SN - 1556-3790
IS - 2
ER -
