The adenomatous polyposis coli tumor suppressor protein and microtubule dynamics

Anke Brüning-Richardson, Ewan E. Morrison

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Colorectal cancer is closely associated with mutation of the gene encoding the adenomatous polyposis coli (APC) tumor suppressor protein. A role has been defined for APC in the Wnt signaling pathway, in which it is responsible for mediating the degradation of the protein β-catenin. This function is clearly responsible for the tumor suppressor activity of APC. However, other APC functions have been identified, notably involving the cytoskeleton, the loss of which may be involved in shaping the phenotype or contributing to the progression of colorectal cancer. Here we provide an insight into recent developments in the study of APC interactions with cytoskeletal elements.

Original languageEnglish
Pages (from-to)82-86
Number of pages5
JournalCurrent Colorectal Cancer Reports
Volume3
Issue number2
DOIs
Publication statusPublished - 1 May 2007
Externally publishedYes

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Adenomatous Polyposis Coli Protein
Tumor Suppressor Proteins
Adenomatous Polyposis Coli
Microtubules
Colorectal Neoplasms
Catenins
Wnt Signaling Pathway
Cytoskeleton
Proteolysis
Phenotype
Mutation
Genes
Neoplasms

Cite this

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The adenomatous polyposis coli tumor suppressor protein and microtubule dynamics. / Brüning-Richardson, Anke; Morrison, Ewan E.

In: Current Colorectal Cancer Reports, Vol. 3, No. 2, 01.05.2007, p. 82-86.

Research output: Contribution to journalArticle

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