The application of phenotypic microarray analysis to anti-fungal drug development

Darren Greetham; David F. Lappin; Ranjith Rajendran; Lindsay O'Donnell; Leighann Sherry; Gordon Ramage; Christopher Nile

doi:10.1016/j.mimet.2017.01.004

The application of phenotypic microarray analysis to anti-fungal drug development

Darren Greetham, David F. Lappin, Ranjith Rajendran, Lindsay O'Donnell, Leighann Sherry, Gordon Ramage, Christopher Nile

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Candida albicans metabolic activity in the presence and absence of acetylcholine was measured using phenotypic microarray analysis. Acetylcholine inhibited C. albicans biofilm formation by slowing metabolism independent of biofilm forming capabilities. Phenotypic microarray analysis can therefore be used for screening compound libraries for novel anti-fungal drugs and measuring antifungal resistance.

Original language	English
Pages (from-to)	35-37
Number of pages	3
Journal	Journal of Microbiological Methods
Volume	134
Early online date	9 Jan 2017
DOIs	https://doi.org/10.1016/j.mimet.2017.01.004
Publication status	Published - 1 Mar 2017
Externally published	Yes

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title = "The application of phenotypic microarray analysis to anti-fungal drug development",

abstract = "Candida albicans metabolic activity in the presence and absence of acetylcholine was measured using phenotypic microarray analysis. Acetylcholine inhibited C. albicans biofilm formation by slowing metabolism independent of biofilm forming capabilities. Phenotypic microarray analysis can therefore be used for screening compound libraries for novel anti-fungal drugs and measuring antifungal resistance.",

keywords = "Acetylcholine, Anti-fungal, Candida albicans, Metabolism, Phenotypic microarray, Resistance",

author = "Darren Greetham and Lappin, {David F.} and Ranjith Rajendran and Lindsay O'Donnell and Leighann Sherry and Gordon Ramage and Christopher Nile",

year = "2017",

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doi = "10.1016/j.mimet.2017.01.004",

language = "English",

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journal = "Journal of Microbiological Methods",

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T1 - The application of phenotypic microarray analysis to anti-fungal drug development

AU - Greetham, Darren

AU - Lappin, David F.

AU - Rajendran, Ranjith

AU - O'Donnell, Lindsay

AU - Sherry, Leighann

AU - Ramage, Gordon

AU - Nile, Christopher

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Candida albicans metabolic activity in the presence and absence of acetylcholine was measured using phenotypic microarray analysis. Acetylcholine inhibited C. albicans biofilm formation by slowing metabolism independent of biofilm forming capabilities. Phenotypic microarray analysis can therefore be used for screening compound libraries for novel anti-fungal drugs and measuring antifungal resistance.

AB - Candida albicans metabolic activity in the presence and absence of acetylcholine was measured using phenotypic microarray analysis. Acetylcholine inhibited C. albicans biofilm formation by slowing metabolism independent of biofilm forming capabilities. Phenotypic microarray analysis can therefore be used for screening compound libraries for novel anti-fungal drugs and measuring antifungal resistance.

KW - Acetylcholine

KW - Anti-fungal

KW - Candida albicans

KW - Metabolism

KW - Phenotypic microarray

KW - Resistance

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U2 - 10.1016/j.mimet.2017.01.004

DO - 10.1016/j.mimet.2017.01.004

M3 - Article

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AN - SCOPUS:85009193593

VL - 134

SP - 35

EP - 37

JO - Journal of Microbiological Methods

JF - Journal of Microbiological Methods

SN - 0167-7012

ER -

The application of phenotypic microarray analysis to anti-fungal drug development

Abstract

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