The application of phenotypic microarray analysis to anti-fungal drug development

Darren Greetham, David F. Lappin, Ranjith Rajendran, Lindsay O'Donnell, Leighann Sherry, Gordon Ramage, Christopher Nile

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Candida albicans metabolic activity in the presence and absence of acetylcholine was measured using phenotypic microarray analysis. Acetylcholine inhibited C. albicans biofilm formation by slowing metabolism independent of biofilm forming capabilities. Phenotypic microarray analysis can therefore be used for screening compound libraries for novel anti-fungal drugs and measuring antifungal resistance.

Original languageEnglish
Pages (from-to)35-37
Number of pages3
JournalJournal of Microbiological Methods
Volume134
Early online date9 Jan 2017
DOIs
Publication statusPublished - 1 Mar 2017
Externally publishedYes

Fingerprint

Microarray Analysis
Biofilms
Candida albicans
Acetylcholine
Fungal Drug Resistance
Pharmaceutical Preparations
Libraries

Cite this

Greetham, Darren ; Lappin, David F. ; Rajendran, Ranjith ; O'Donnell, Lindsay ; Sherry, Leighann ; Ramage, Gordon ; Nile, Christopher. / The application of phenotypic microarray analysis to anti-fungal drug development. In: Journal of Microbiological Methods. 2017 ; Vol. 134. pp. 35-37.
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The application of phenotypic microarray analysis to anti-fungal drug development. / Greetham, Darren; Lappin, David F.; Rajendran, Ranjith; O'Donnell, Lindsay; Sherry, Leighann; Ramage, Gordon; Nile, Christopher.

In: Journal of Microbiological Methods, Vol. 134, 01.03.2017, p. 35-37.

Research output: Contribution to journalArticle

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AU - Ramage, Gordon

AU - Nile, Christopher

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