The Challenge of Atropisomerism in Drug Discovery

Jonathan Clayden, Wesley J. Moran, Paul J. Edwards, Steven R. Laplante

Research output: Contribution to journalArticle

266 Citations (Scopus)

Abstract

A twist in the tale: Recent reports have highlighted solutions to the problems encountered when drug candidates exist as slowly interconverting conformers or atropisomers (see scheme). This Minireview brings together the various strategies that have been adopted and proposes a general approach to handling an aspect of stereochemistry which has received little attention from drug regulatory agencies.

Original languageEnglish
Pages (from-to)6398-6401
Number of pages4
JournalAngewandte Chemie - International Edition
Volume48
Issue number35
Early online date27 Jul 2009
DOIs
Publication statusPublished - 17 Aug 2009
Externally publishedYes

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Stereochemistry
Pharmaceutical Preparations
Drug Discovery

Cite this

Clayden, Jonathan ; Moran, Wesley J. ; Edwards, Paul J. ; Laplante, Steven R. / The Challenge of Atropisomerism in Drug Discovery. In: Angewandte Chemie - International Edition. 2009 ; Vol. 48, No. 35. pp. 6398-6401.
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The Challenge of Atropisomerism in Drug Discovery. / Clayden, Jonathan; Moran, Wesley J.; Edwards, Paul J.; Laplante, Steven R.

In: Angewandte Chemie - International Edition, Vol. 48, No. 35, 17.08.2009, p. 6398-6401.

Research output: Contribution to journalArticle

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