The Chemical Reactivity of β-Lactams, β-Sultams and β-Phospholactams

Michael I. Page, Andrew P. Laws

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)


β-Lactam antibiotics display a range of biological activities. The origin of this diverse biological activity is discussed with reference to the chemical reactivity of the small ring system. The reactions of β-sultams and β-phospholactams with simple nucleophiles are reported and their potential as mechanism based inhibitors of bacterial and mammalian serine proteases is described. 

Original languageEnglish
Pages (from-to)5631-5638
Number of pages8
Issue number31
Publication statusPublished - 28 Jul 2000


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