The Chemical Reactivity of β-Lactams, β-Sultams and β-Phospholactams

Michael I. Page, Andrew P. Laws

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

β-Lactam antibiotics display a range of biological activities. The origin of this diverse biological activity is discussed with reference to the chemical reactivity of the small ring system. The reactions of β-sultams and β-phospholactams with simple nucleophiles are reported and their potential as mechanism based inhibitors of bacterial and mammalian serine proteases is described. 

LanguageEnglish
Pages5631-5638
Number of pages8
JournalTetrahedron
Volume56
Issue number31
DOIs
Publication statusPublished - 28 Jul 2000

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Chemical reactivity
beta-Lactams
Serine Proteases
Bioactivity
Anti-Bacterial Agents
Nucleophiles
beta-sultam

Cite this

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The Chemical Reactivity of β-Lactams, β-Sultams and β-Phospholactams. / Page, Michael I.; Laws, Andrew P.

In: Tetrahedron, Vol. 56, No. 31, 28.07.2000, p. 5631-5638.

Research output: Contribution to journalArticle

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