The Chemical Reactivity of β-Lactams, β-Sultams and β-Phospholactams

Michael I. Page; Andrew P. Laws

doi:10.1016/S0040-4020(00)00412-9

The Chemical Reactivity of β-Lactams, β-Sultams and β-Phospholactams

Michael I. Page, Andrew P. Laws

Research output: Contribution to journal › Article › peer-review

67 Citations (Scopus)

Abstract

β-Lactam antibiotics display a range of biological activities. The origin of this diverse biological activity is discussed with reference to the chemical reactivity of the small ring system. The reactions of β-sultams and β-phospholactams with simple nucleophiles are reported and their potential as mechanism based inhibitors of bacterial and mammalian serine proteases is described.

Original language	English
Pages (from-to)	5631-5638
Number of pages	8
Journal	Tetrahedron
Volume	56
Issue number	31
DOIs	https://doi.org/10.1016/S0040-4020(00)00412-9
Publication status	Published - 28 Jul 2000

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10.1016/S0040-4020(00)00412-9

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abstract = "β-Lactam antibiotics display a range of biological activities. The origin of this diverse biological activity is discussed with reference to the chemical reactivity of the small ring system. The reactions of β-sultams and β-phospholactams with simple nucleophiles are reported and their potential as mechanism based inhibitors of bacterial and mammalian serine proteases is described. ",

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AU - Laws, Andrew P.

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AB - β-Lactam antibiotics display a range of biological activities. The origin of this diverse biological activity is discussed with reference to the chemical reactivity of the small ring system. The reactions of β-sultams and β-phospholactams with simple nucleophiles are reported and their potential as mechanism based inhibitors of bacterial and mammalian serine proteases is described.

KW - β-Lactamase inhibitors

KW - β-Lactams

KW - β-Phospholactams

KW - β-Sultams

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JO - Tetrahedron

JF - Tetrahedron

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ER -

The Chemical Reactivity of β-Lactams, β-Sultams and β-Phospholactams

Abstract

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