The Collaborative IPD of Sleep and Stillbirth (Cribss): is maternal going-to-sleep position a risk factor for late stillbirth and does maternal sleep position interact with fetal vulnerability? An individual participant data meta-analysis study protocol

Minglan Li, John MD Thompson, Robin S Cronin, Adrienne Gordon, Camille Raynes-Greenow, Alexander EP Heazell, Tomasina Stacey, Vicki Culling, Victoria Bowring, Edwin A Mitchell, Lesley Me Mccowan, Lisa Askie

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Introduction: Accumulating evidence has shown an association between maternal supine going-to-sleep position and stillbirth in late pregnancy. Advising women not to go-to-sleep on their back can potentially reduce late stillbirth rate by 9%. However, the association between maternal right-sided going-to-sleep position and stillbirth is inconsistent across studies. Furthermore, individual studies are underpowered to investigate interactions between maternal going-to-sleep position and fetal vulnerability, which is potentially important for producing clear and tailored public health messages on safe going-to-sleep position. We will use individual participant data (IPD) from existing studies to assess whether right-side and supine going-to-sleep positions are independent risk factors for late stillbirth and to test the interaction between going-to-sleep position and fetal vulnerability.

Methods and analysis: An IPD meta-analysis approach will be used using the Cochrane Collaboration-endorsed methodology. We will identify case–control and prospective cohort studies and randomised trials which collected maternal going-to-sleep position data and pregnancy outcome data that included stillbirth. The primary outcome is stillbirth. A one stage procedure meta-analysis, stratified by study with adjustment of a priori confounders will be carried out.

Ethics and dissemination: The IPD meta-analysis has obtained central ethics approval from the New Zealand Health and Disability Ethics Committee, ref: NTX/06/05/054/AM06. Individual studies should also have ethical approval from relevant local ethics committees. Interpretation of the results will be discussed with consumer representatives. Results of the study will be published in peer-reviewed journals and presented at international conferences.
LanguageEnglish
Article numbere020323
Pages1-6
Number of pages6
JournalBMJ Open
Volume8
Issue number4
DOIs
Publication statusPublished - 1 Apr 2018
Externally publishedYes

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Stillbirth
Meta-Analysis
Sleep
Mothers
Ethics Committees
Ethics
Social Adjustment
Pregnancy Outcome
New Zealand
Cohort Studies
Public Health
Prospective Studies
Pregnancy
Health

Cite this

Li, Minglan ; Thompson, John MD ; Cronin, Robin S ; Gordon, Adrienne ; Raynes-Greenow, Camille ; Heazell, Alexander EP ; Stacey, Tomasina ; Culling, Vicki ; Bowring, Victoria ; Mitchell, Edwin A ; Mccowan, Lesley Me ; Askie, Lisa. / The Collaborative IPD of Sleep and Stillbirth (Cribss) : is maternal going-to-sleep position a risk factor for late stillbirth and does maternal sleep position interact with fetal vulnerability? An individual participant data meta-analysis study protocol. In: BMJ Open. 2018 ; Vol. 8, No. 4. pp. 1-6.
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abstract = "Introduction: Accumulating evidence has shown an association between maternal supine going-to-sleep position and stillbirth in late pregnancy. Advising women not to go-to-sleep on their back can potentially reduce late stillbirth rate by 9{\%}. However, the association between maternal right-sided going-to-sleep position and stillbirth is inconsistent across studies. Furthermore, individual studies are underpowered to investigate interactions between maternal going-to-sleep position and fetal vulnerability, which is potentially important for producing clear and tailored public health messages on safe going-to-sleep position. We will use individual participant data (IPD) from existing studies to assess whether right-side and supine going-to-sleep positions are independent risk factors for late stillbirth and to test the interaction between going-to-sleep position and fetal vulnerability.Methods and analysis: An IPD meta-analysis approach will be used using the Cochrane Collaboration-endorsed methodology. We will identify case–control and prospective cohort studies and randomised trials which collected maternal going-to-sleep position data and pregnancy outcome data that included stillbirth. The primary outcome is stillbirth. A one stage procedure meta-analysis, stratified by study with adjustment of a priori confounders will be carried out.Ethics and dissemination: The IPD meta-analysis has obtained central ethics approval from the New Zealand Health and Disability Ethics Committee, ref: NTX/06/05/054/AM06. Individual studies should also have ethical approval from relevant local ethics committees. Interpretation of the results will be discussed with consumer representatives. Results of the study will be published in peer-reviewed journals and presented at international conferences.",
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The Collaborative IPD of Sleep and Stillbirth (Cribss) : is maternal going-to-sleep position a risk factor for late stillbirth and does maternal sleep position interact with fetal vulnerability? An individual participant data meta-analysis study protocol. / Li, Minglan; Thompson, John MD; Cronin, Robin S; Gordon, Adrienne; Raynes-Greenow, Camille; Heazell, Alexander EP; Stacey, Tomasina; Culling, Vicki; Bowring, Victoria; Mitchell, Edwin A; Mccowan, Lesley Me; Askie, Lisa.

In: BMJ Open, Vol. 8, No. 4, e020323, 01.04.2018, p. 1-6.

Research output: Contribution to journalArticle

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T1 - The Collaborative IPD of Sleep and Stillbirth (Cribss)

T2 - BMJ Open

AU - Li, Minglan

AU - Thompson, John MD

AU - Cronin, Robin S

AU - Gordon, Adrienne

AU - Raynes-Greenow, Camille

AU - Heazell, Alexander EP

AU - Stacey, Tomasina

AU - Culling, Vicki

AU - Bowring, Victoria

AU - Mitchell, Edwin A

AU - Mccowan, Lesley Me

AU - Askie, Lisa

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Introduction: Accumulating evidence has shown an association between maternal supine going-to-sleep position and stillbirth in late pregnancy. Advising women not to go-to-sleep on their back can potentially reduce late stillbirth rate by 9%. However, the association between maternal right-sided going-to-sleep position and stillbirth is inconsistent across studies. Furthermore, individual studies are underpowered to investigate interactions between maternal going-to-sleep position and fetal vulnerability, which is potentially important for producing clear and tailored public health messages on safe going-to-sleep position. We will use individual participant data (IPD) from existing studies to assess whether right-side and supine going-to-sleep positions are independent risk factors for late stillbirth and to test the interaction between going-to-sleep position and fetal vulnerability.Methods and analysis: An IPD meta-analysis approach will be used using the Cochrane Collaboration-endorsed methodology. We will identify case–control and prospective cohort studies and randomised trials which collected maternal going-to-sleep position data and pregnancy outcome data that included stillbirth. The primary outcome is stillbirth. A one stage procedure meta-analysis, stratified by study with adjustment of a priori confounders will be carried out.Ethics and dissemination: The IPD meta-analysis has obtained central ethics approval from the New Zealand Health and Disability Ethics Committee, ref: NTX/06/05/054/AM06. Individual studies should also have ethical approval from relevant local ethics committees. Interpretation of the results will be discussed with consumer representatives. Results of the study will be published in peer-reviewed journals and presented at international conferences.

AB - Introduction: Accumulating evidence has shown an association between maternal supine going-to-sleep position and stillbirth in late pregnancy. Advising women not to go-to-sleep on their back can potentially reduce late stillbirth rate by 9%. However, the association between maternal right-sided going-to-sleep position and stillbirth is inconsistent across studies. Furthermore, individual studies are underpowered to investigate interactions between maternal going-to-sleep position and fetal vulnerability, which is potentially important for producing clear and tailored public health messages on safe going-to-sleep position. We will use individual participant data (IPD) from existing studies to assess whether right-side and supine going-to-sleep positions are independent risk factors for late stillbirth and to test the interaction between going-to-sleep position and fetal vulnerability.Methods and analysis: An IPD meta-analysis approach will be used using the Cochrane Collaboration-endorsed methodology. We will identify case–control and prospective cohort studies and randomised trials which collected maternal going-to-sleep position data and pregnancy outcome data that included stillbirth. The primary outcome is stillbirth. A one stage procedure meta-analysis, stratified by study with adjustment of a priori confounders will be carried out.Ethics and dissemination: The IPD meta-analysis has obtained central ethics approval from the New Zealand Health and Disability Ethics Committee, ref: NTX/06/05/054/AM06. Individual studies should also have ethical approval from relevant local ethics committees. Interpretation of the results will be discussed with consumer representatives. Results of the study will be published in peer-reviewed journals and presented at international conferences.

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DO - 10.1136/bmjopen-2017-020323

M3 - Article

VL - 8

SP - 1

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JO - BMJ Open

JF - BMJ Open

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