The complex landscape of vaccine hesitancy and hesitant adopters: Quantitative predictors and thematic insights into COVID-19 vaccine attitudes

Gabriella Annandale, Susanna Kola-Palmer, Eilish Duke

Research output: Contribution to journalArticlepeer-review

Abstract

Vaccine hesitancy is one of the top 10 threats to public health. The COVID-19 pandemic and associated vaccinations marked a watershed moment for vaccine hesitancy, with highly publicized anti-vaccine protests, and widespread misinformation and distrust of the novel vaccines. This mixed-method survey sought to provide a nuanced understanding of vaccine hesitancy and hesitant vaccine adopters in the context of the COVID-19 vaccination. N = 410 participants completed an online survey comprising a battery of psychometric measures of vaccine hesitancy, personality, conspiracy belief, and political affiliation. N = 134 participants, who identified as vaccine hesitant toward the novel vaccine, provided additional written qualitative responses detailing the reasons they were hesitant about accepting the COVID-19 vaccination. Quantitative findings point to higher hesitancy among males, those with high-school and undergraduate levels of education, mixed- and minoritized ethnic groups (Black, Asian), and those higher in Right-Wing Authoritarian and Conspiracy beliefs. Qualitative data unveiled six themes underpinning hesitancy: side-effect concerns; Covid risk perception; conspiracy and religious beliefs; psychological reactance against perceived coercion; a perceived lack of information; and distrust of Government/medical establishments. Crucially, an acknowledgment of the benefits of the vaccine, e.g. in terms of protecting others, distinguished vaccine hesitant adopters from refusers. Implications of the findings are discussed with a view to informing policy and public health campaigns targeting vaccine hesitant adopters.

Original languageEnglish
Article number2511350
Number of pages13
JournalHuman Vaccines and Immunotherapeutics
Volume21
Issue number1
Early online date20 Jun 2025
DOIs
Publication statusPublished - 1 Jul 2025

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