Although cemented total hip replacement has long been recognized as a situation that can lead to wear, the wear generated on the femoral stem has not been well documented, especially with regard to how this wear is initiated and propagated. This present work aimed to further investigate this issue based on a comprehensive study on surface morphology of the femoral stem and the bone cement, which were collected from seven in vitro wear simulations. It was shown that the wear locations on the stem surface compared well with the results of retrieval studies, and the boundaries of the worn areas matched well the edges of the micropores present in the bone cement surface. This indicated that the micropores could potentially contribute to the generation of femoral stem wear. In addition, metallic debris was detected around the micropores from the simulation with increased loading cycles. However, no evidence of macro-cracks was observed across the cement mantle in spite of the presence of micro-cracks initiated at the edge of the micropores. This study demonstrated a possible cause for progression of femoral stem wear and it may have an important bearing on the long term durability of cemented hip prosthesis.