The design of naproxen solid lipid nanoparticles to target skin layers

Jafar Akbari, Majid Saeedi, Katayoun Morteza-Semnani, Seyyed Sohrab Rostamkalaei, Masoumeh Asadi, Kofi Asare-Addo, Ali Nokhodchi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The aim of the current investigation was to produce naproxen solid lipid nanoparticles (Nap-SLNs) by the ultrasonication method to improve its skin permeation and also to investigate the influence of Hydrophilic-lipophilic balance (HLB) changes on nanoparticles properties. The properties of obtained SLNs loaded with naproxen were characterized by photon correlation spectroscopy (PCS), transmission electron microscopy (TEM) and differential scanning calorimetry (DSC). FT-IR was also used to investigate any interaction between naproxen and the excipients used at the molecular level during the preparation of the SLNs. The performance of the formulations was investigated in terms of skin permeation and also the retention of the drug by the skin. It was found that generally, with increasing the lipid concentration, the average particle size and polydispersity index (PDI) of SLNs increased from 94.257 ± 4.852 nm to 143.90 ± 2.685 nm and from 0.293 ± 0.037 to 0.525 ± 0.038 respectively. The results also showed that a reduction in the HLB resulted in an increase in the PDI, particle size, zeta potential and entrapment efficiency (EE%). DSC showed that the naproxen encapsulated in the SLNs was in its amorphous form. The peaks of prominent functional groups of naproxen were found in the FT-IR spectra of naproxen-SLN, which confirmed the entrapment of naproxen in the lipid matrix. FT-IR results also ruled out any chemical interaction between drug and the chemicals used in the preparation of SLNs. The amount of naproxen detected in the receptor chamber at all the sampling times for the reference formulation (naproxen solution containing all surfactants at pH 7.4) was higher than that of the Nap-SLN8 formulation. Nap-SLN8 showed an increase in the concentration of naproxen in the skin layer with less systemic absorption. This indicates that most of the drug in Nap-SLN8 remains in the skin which can reduce the side effect of systemic absorption of the drug and increases the concentration of the drug at the site of the action.

LanguageEnglish
Pages626-633
Number of pages8
JournalColloids and Surfaces B: Biointerfaces
Volume145
Early online date25 May 2016
DOIs
Publication statusPublished - 1 Sep 2016

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Naproxen
Nanoparticles
Lipids
lipids
Skin
drugs
nanoparticles
entrapment
Polydispersity
formulations
Permeation
Differential scanning calorimetry
heat measurement
Particle size
Drug interactions
Photon correlation spectroscopy
preparation
scanning
Differential Scanning Calorimetry
Zeta potential

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Akbari, J., Saeedi, M., Morteza-Semnani, K., Rostamkalaei, S. S., Asadi, M., Asare-Addo, K., & Nokhodchi, A. (2016). The design of naproxen solid lipid nanoparticles to target skin layers. Colloids and Surfaces B: Biointerfaces, 145, 626-633. https://doi.org/10.1016/j.colsurfb.2016.05.064
Akbari, Jafar ; Saeedi, Majid ; Morteza-Semnani, Katayoun ; Rostamkalaei, Seyyed Sohrab ; Asadi, Masoumeh ; Asare-Addo, Kofi ; Nokhodchi, Ali. / The design of naproxen solid lipid nanoparticles to target skin layers. In: Colloids and Surfaces B: Biointerfaces. 2016 ; Vol. 145. pp. 626-633.
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Akbari, J, Saeedi, M, Morteza-Semnani, K, Rostamkalaei, SS, Asadi, M, Asare-Addo, K & Nokhodchi, A 2016, 'The design of naproxen solid lipid nanoparticles to target skin layers', Colloids and Surfaces B: Biointerfaces, vol. 145, pp. 626-633. https://doi.org/10.1016/j.colsurfb.2016.05.064

The design of naproxen solid lipid nanoparticles to target skin layers. / Akbari, Jafar; Saeedi, Majid; Morteza-Semnani, Katayoun; Rostamkalaei, Seyyed Sohrab; Asadi, Masoumeh; Asare-Addo, Kofi; Nokhodchi, Ali.

In: Colloids and Surfaces B: Biointerfaces, Vol. 145, 01.09.2016, p. 626-633.

Research output: Contribution to journalArticle

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AU - Akbari, Jafar

AU - Saeedi, Majid

AU - Morteza-Semnani, Katayoun

AU - Rostamkalaei, Seyyed Sohrab

AU - Asadi, Masoumeh

AU - Asare-Addo, Kofi

AU - Nokhodchi, Ali

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