This chapter argues that treating these stories as dramas enables people to understand the place and significance of medicines in people’s lives. It describes how stories about medicine taking can be conceived as dramas of medicines in the body, signification and the self, and experimentation in accounts of living with postural tachycardia syndrome, a rare dysfunction of the autonomic nervous system. Managing illness, including its self-management through day-to-day care practices, requires the cooperation of diverse groups of individual and collective actors, shared spaces, material things and processes in the accomplishment of what can be quite heterogeneous goals. Anthropological work on pharmaceuticals has illuminated the range of actors engaged in their ‘life cycle’ from development, manufacture and commercial marketing, to prescribing, dispensing and consumption. The management of Postural tachycardia syndrome (PoTS) tends to involve both pharmacological and non-pharmacological approaches.