The effect of obstructive sleep apnea on retinal arterial and venous oxygen saturations: further evidence from a randomised study

Chris D. Turnbull; John R. Stradling; Rebekka Heitmar

doi:10.1007/s00417-023-05973-x

The effect of obstructive sleep apnea on retinal arterial and venous oxygen saturations: further evidence from a randomised study

Chris D. Turnbull, John R. Stradling, Rebekka Heitmar

Research output: Contribution to journal › Letter › peer-review

Abstract

Obstructive sleep apnea (OSA) is associated with retinal vascular diseases, but the mechanisms by which OSA might cause retinal vascular disease are unknown.

To our knowledge, this is the first randomised controlled study to explore the effects of OSA on awake retinal oxygen saturations, as a surrogate of oxygen delivery.

Stopping continuous positive airway pressure had no effect on daytime retinal arterial or venous oxygen saturations, despite leading to a marked return of OSA.

This suggests that OSA does not alter daytime oxygen delivery and suggests that other mechanisms are responsible for retinal vascular disease in OSA.

Original language	English
Pages (from-to)	1757-1759
Number of pages	3
Journal	Graefe's Archive for Clinical and Experimental Ophthalmology
Volume	261
Issue number	6
Early online date	14 Jan 2023
DOIs	https://doi.org/10.1007/s00417-023-05973-x
Publication status	Published - 1 Jun 2023

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abstract = "Obstructive sleep apnea (OSA) is associated with retinal vascular diseases, but the mechanisms by which OSA might cause retinal vascular disease are unknown. To our knowledge, this is the first randomised controlled study to explore the effects of OSA on awake retinal oxygen saturations, as a surrogate of oxygen delivery. Stopping continuous positive airway pressure had no effect on daytime retinal arterial or venous oxygen saturations, despite leading to a marked return of OSA. This suggests that OSA does not alter daytime oxygen delivery and suggests that other mechanisms are responsible for retinal vascular disease in OSA.",

keywords = "Obstructive sleep apnea (OSA), retinal vascular disease, retinal blood flow, venous oxygen saturation",

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note = "Funding Information: This study was funded by the Oxford Radcliffe Hospitals Charitable Fund 0189 and the ResMed Foundation. Neither funder had any role in the design, conduct, or analysis of this study. ",

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AU - Turnbull, Chris D.

AU - Stradling, John R.

AU - Heitmar, Rebekka

N1 - Funding Information: This study was funded by the Oxford Radcliffe Hospitals Charitable Fund 0189 and the ResMed Foundation. Neither funder had any role in the design, conduct, or analysis of this study.

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N2 - Obstructive sleep apnea (OSA) is associated with retinal vascular diseases, but the mechanisms by which OSA might cause retinal vascular disease are unknown. To our knowledge, this is the first randomised controlled study to explore the effects of OSA on awake retinal oxygen saturations, as a surrogate of oxygen delivery. Stopping continuous positive airway pressure had no effect on daytime retinal arterial or venous oxygen saturations, despite leading to a marked return of OSA. This suggests that OSA does not alter daytime oxygen delivery and suggests that other mechanisms are responsible for retinal vascular disease in OSA.

AB - Obstructive sleep apnea (OSA) is associated with retinal vascular diseases, but the mechanisms by which OSA might cause retinal vascular disease are unknown. To our knowledge, this is the first randomised controlled study to explore the effects of OSA on awake retinal oxygen saturations, as a surrogate of oxygen delivery. Stopping continuous positive airway pressure had no effect on daytime retinal arterial or venous oxygen saturations, despite leading to a marked return of OSA. This suggests that OSA does not alter daytime oxygen delivery and suggests that other mechanisms are responsible for retinal vascular disease in OSA.

KW - Obstructive sleep apnea (OSA)

KW - retinal vascular disease

KW - retinal blood flow

KW - venous oxygen saturation

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DO - 10.1007/s00417-023-05973-x

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JO - Graefe's Archive for Clinical and Experimental Ophthalmology

JF - Graefe's Archive for Clinical and Experimental Ophthalmology

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ER -

The effect of obstructive sleep apnea on retinal arterial and venous oxygen saturations: further evidence from a randomised study

Abstract

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