The effect of simulated cataract light scatter on retinal vessel oximetry

Sunni R. Patel, Chris Hudson, John G. Flanagan, Rebekka Heitmar

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

To assess the impact of light scatter, similar to that introduced by cataract on retinal vessel blood oxygen saturation measurements using poly-bead solutions of varying concentrations. Eight healthy, young, non-smoking individuals were enrolled for this study. All subjects underwent digital blood pressure measurements, assessment of non-contact intraocular pressure, pupil dilation and retinal vessel oximetry using dual wavelength photography (Oximetry Module, Imedos Systems, Germany). To simulate light scatter, cells comprising a plastic collar and two plano lenses were filled with solutions of differing concentrations (0.001, 0.002 and 0.004%) of polystyrene microspheres (Polysciences Inc., USA). The adopted light scatter model showed an artifactual increase in venous optical density ratio (p=0.036), with the 0.004% condition producing significantly higher venous optical density ratio values when compared to images without a cell in place. Spectrophotometric analysis, and thus retinal vessel oximetry of the retinal vessels, is altered by artificial light scatter.

Original languageEnglish
Pages (from-to)185-189
Number of pages5
JournalExperimental Eye Research
Volume116
Early online date19 Sep 2013
DOIs
Publication statusPublished - 1 Nov 2013
Externally publishedYes

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