The effect of voluntary fasting and dehydration on flicker-induced retinal vascular dilation in a healthy individual: A case report

Rebekka Heitmar; Doina Gherghel; Richard Armstrong; Robert Cubbidge; Sarah Hosking

doi:10.1186/1752-1947-2-153

The effect of voluntary fasting and dehydration on flicker-induced retinal vascular dilation in a healthy individual: A case report

Rebekka Heitmar, Doina Gherghel, Richard Armstrong, Robert Cubbidge, Sarah Hosking

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Introduction: Dynamic retinal vessel analysis represents a well-established method for the assessment of vascular reactivity during both normal conditions and after various provocations. We present a case where the subject showed abnormal retinal vessel reactivity after fasting voluntarily for 20 hours. Case presentation: A healthy, 21-year-old man who fasted voluntarily for 20 hours exhibited abnormal retinal vascular reactivity (dilation and constriction) after flicker provocation as measured using the Dynamic Retinal Vessel Analyser (Imedos, Jena, Germany). Conclusion: The abnormal vascular reactivity induced by fasting was significant; abnormal levels of important nutrients due to fasting and dehydration could play a role through altering the concentration of vasoactive substances such as nitric oxide. This hypothesis needs further investigation.

Original language	English
Article number	153
Number of pages	7
Journal	Journal of Medical Case Reports
Volume	2
DOIs	https://doi.org/10.1186/1752-1947-2-153
Publication status	Published - 13 May 2008
Externally published	Yes

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10.1186/1752-1947-2-153Licence: CC BY

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AU - Gherghel, Doina

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AU - Cubbidge, Robert

AU - Hosking, Sarah

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AB - Introduction: Dynamic retinal vessel analysis represents a well-established method for the assessment of vascular reactivity during both normal conditions and after various provocations. We present a case where the subject showed abnormal retinal vessel reactivity after fasting voluntarily for 20 hours. Case presentation: A healthy, 21-year-old man who fasted voluntarily for 20 hours exhibited abnormal retinal vascular reactivity (dilation and constriction) after flicker provocation as measured using the Dynamic Retinal Vessel Analyser (Imedos, Jena, Germany). Conclusion: The abnormal vascular reactivity induced by fasting was significant; abnormal levels of important nutrients due to fasting and dehydration could play a role through altering the concentration of vasoactive substances such as nitric oxide. This hypothesis needs further investigation.

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The effect of voluntary fasting and dehydration on flicker-induced retinal vascular dilation in a healthy individual: A case report

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