The effectiveness of mRNA‐1273 vaccine against COVID‐19 caused by delta variant: A systematic review and meta‐analysis

Chia Siang Kow, Dinesh Sangarran Ramachandram, Syed Shahzad Hasan

Research output: Contribution to journalReview articlepeer-review

Abstract

We aimed to perform meta-analyses to summarize the overall effectiveness of mRNA-1273 vaccine against COVID-19 caused by delta variant from large real-world studies. A systematic literature search with no language restriction was performed in electronic databases to identify eligible observational studies that reported the effectiveness of the mRNA-1273 vaccine to prevent reverse transcription-polymerase chain reaction (RT-PCR) confirmed COVID-19 caused by delta variant of SARS-CoV-2 (B.1.617.2). Random-effects meta-analysis model was used to estimate the pooled odds ratio (OR) at a 95% confidence interval, and the vaccine effectiveness was indicated as (pooled OR – 1)/OR. Five studies were included for this systematic review and meta-analysis. The meta-analysis revealed that the administration of mRNA-1273 vaccine protected against RT-PCR confirmed COVID-19 caused by delta variant ≥21 days post first dose, with pooled vaccine effectiveness of 66% (95% confidence interval 65-67%), as well as ≥14 days post second dose, with pooled vaccine effectiveness of 91% (95% confidence interval: 84-95%). In conclusion, the mRNA-1273 vaccine offers a substantial protection rate against RT-PCR confirmed COVID-19 caused by the delta variant upon full vaccination, albeit with slightly reduced effectiveness relative to other strains of SARS-CoV-2.
Original languageEnglish
JournalJournal of Medical Virology
Early online date3 Jan 2022
DOIs
Publication statusE-pub ahead of print - 3 Jan 2022

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