The effects of cannabidiol and tetrahydrocannabinol on motion-induced emesis in Suncus murinus

Nina L. Cluny, Robert J. Naylor, Brian A. Whittle, Farideh A. Javid

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The effect of cannabinoids on motion-induced emesis is unknown. The present study investigated the action of phytocannabinoids against motion-induced emesis in Suncus murinus. Suncus murinus were injected intraperitoneally with either cannabidiol (CBD) (0.5, 1, 2, 5, 10, 20 and 40 mg/kg), Δ9-tetrahydrocannabinol (Δ9-THC; 0.5, 3, 5 and 10 mg/kg) or vehicle 45 min. before exposure to a 10-min. horizontal motion stimulus (amplitude 40 mm, frequency 1 Hz). In further investigations, the CB1 receptor antagonist, N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4- dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM 251; 5 mg/kg), was injected 15 min. prior to an injection of Δ9-THC (3 mg/kg). The motion stimulus was applied 45 min. later. The number of emetic episodes and latency of onset to the first emetic episode were recorded. Pre-treatment with the above doses of CBD did not modify the emetic response to the motion stimulus as compared to the vehicle-treated controls. Application of the higher doses of Δ9-THC induced emesis in its own right, which was inhibited by AM 251. Furthermore, pre-treatment with Δ9-THC dose-dependently attenuated motion-induced emesis, an effect that was inhibited by AM 251. AM 251 neither induced an emetic response nor modified motion-induced emesis. The present study indicates that Δ9-THC, acting via the CB1 receptors, is anti-emetic to motion, and that CBD has no effect on motion-induced emesis in Suncus murinus.

Original languageEnglish
Pages (from-to)150-156
Number of pages7
JournalBasic and Clinical Pharmacology and Toxicology
Volume103
Issue number2
DOIs
Publication statusPublished - 1 Aug 2008
Externally publishedYes

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Cannabidiol
Dronabinol
Emetics
Vomiting
Cannabinoid Receptor CB1
Antiemetics
Cannabinoids
AM 251

Cite this

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title = "The effects of cannabidiol and tetrahydrocannabinol on motion-induced emesis in Suncus murinus",
abstract = "The effect of cannabinoids on motion-induced emesis is unknown. The present study investigated the action of phytocannabinoids against motion-induced emesis in Suncus murinus. Suncus murinus were injected intraperitoneally with either cannabidiol (CBD) (0.5, 1, 2, 5, 10, 20 and 40 mg/kg), Δ9-tetrahydrocannabinol (Δ9-THC; 0.5, 3, 5 and 10 mg/kg) or vehicle 45 min. before exposure to a 10-min. horizontal motion stimulus (amplitude 40 mm, frequency 1 Hz). In further investigations, the CB1 receptor antagonist, N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4- dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM 251; 5 mg/kg), was injected 15 min. prior to an injection of Δ9-THC (3 mg/kg). The motion stimulus was applied 45 min. later. The number of emetic episodes and latency of onset to the first emetic episode were recorded. Pre-treatment with the above doses of CBD did not modify the emetic response to the motion stimulus as compared to the vehicle-treated controls. Application of the higher doses of Δ9-THC induced emesis in its own right, which was inhibited by AM 251. Furthermore, pre-treatment with Δ9-THC dose-dependently attenuated motion-induced emesis, an effect that was inhibited by AM 251. AM 251 neither induced an emetic response nor modified motion-induced emesis. The present study indicates that Δ9-THC, acting via the CB1 receptors, is anti-emetic to motion, and that CBD has no effect on motion-induced emesis in Suncus murinus.",
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The effects of cannabidiol and tetrahydrocannabinol on motion-induced emesis in Suncus murinus. / Cluny, Nina L.; Naylor, Robert J.; Whittle, Brian A.; Javid, Farideh A.

In: Basic and Clinical Pharmacology and Toxicology, Vol. 103, No. 2, 01.08.2008, p. 150-156.

Research output: Contribution to journalArticle

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AU - Cluny, Nina L.

AU - Naylor, Robert J.

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AU - Javid, Farideh A.

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