The effects of cannabidiolic acid and cannabidiol on contractility of the gastrointestinal tract of Suncus murinus

Nina L. Cluny, Robert J. Naylor, Brian A. Whittle, Farideh A. Javid

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Cannabidiol (CBD) has been shown to inhibit gastrointestinal (GI) transit in pathophysiologic in vivo models, while having no effect in physiologic controls. The actions of the precursor of CBD, cannabidiolic acid (CBDA), have not been investigated in the GI tract. The actions of these phytocannabinoids on the contractility of the GI tract of Suncus murinus were investigated in the current study. The effects of CBDA and CBD in resting state and pre-contracted isolated intestinal segments, and on the contractile effects of carbachol and electrical field stimulation (EFS) on the intestines of S. murinus were examined. CBDA and CBD induced a reduction in resting tissue tension of isolated intestinal segments which was not blocked by the cannabinoid CB1 receptor antagonist, AM251, the CB 2 receptor antagonist AM630, or tetrodotoxin. CBDA and CBD reduced the magnitude of contractions induced by carbachol and the tension of intestinal segments that were pre-contracted with potassium chloride. In tissues stimulated by EFS, CBDA inhibited contractions induced by lower frequencies (0.1-4.0 Hz) of EFS, while CBD inhibited contractions induced by higher frequencies (4.0-20.0 Hz) of EFS. The data suggest that CBDA and CBD have inhibitory actions on the intestines of S. murinus that are not neuronallymediated or mediated via CB 1 or CB 2 receptors.

LanguageEnglish
Pages1509-1517
Number of pages9
JournalArchives of Pharmacal Research
Volume34
Issue number9
DOIs
Publication statusPublished - 1 Sep 2011

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Cannabidiol
Gastrointestinal Tract
Electric Stimulation
Carbachol
Intestines
Cannabinoid Receptor Antagonists
Gastrointestinal Transit
Tissue
Cannabinoid Receptor CB1
Potassium Chloride
Tetrodotoxin
cannabidiolic acid

Cite this

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abstract = "Cannabidiol (CBD) has been shown to inhibit gastrointestinal (GI) transit in pathophysiologic in vivo models, while having no effect in physiologic controls. The actions of the precursor of CBD, cannabidiolic acid (CBDA), have not been investigated in the GI tract. The actions of these phytocannabinoids on the contractility of the GI tract of Suncus murinus were investigated in the current study. The effects of CBDA and CBD in resting state and pre-contracted isolated intestinal segments, and on the contractile effects of carbachol and electrical field stimulation (EFS) on the intestines of S. murinus were examined. CBDA and CBD induced a reduction in resting tissue tension of isolated intestinal segments which was not blocked by the cannabinoid CB1 receptor antagonist, AM251, the CB 2 receptor antagonist AM630, or tetrodotoxin. CBDA and CBD reduced the magnitude of contractions induced by carbachol and the tension of intestinal segments that were pre-contracted with potassium chloride. In tissues stimulated by EFS, CBDA inhibited contractions induced by lower frequencies (0.1-4.0 Hz) of EFS, while CBD inhibited contractions induced by higher frequencies (4.0-20.0 Hz) of EFS. The data suggest that CBDA and CBD have inhibitory actions on the intestines of S. murinus that are not neuronallymediated or mediated via CB 1 or CB 2 receptors.",
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The effects of cannabidiolic acid and cannabidiol on contractility of the gastrointestinal tract of Suncus murinus. / Cluny, Nina L.; Naylor, Robert J.; Whittle, Brian A.; Javid, Farideh A.

In: Archives of Pharmacal Research, Vol. 34, No. 9, 01.09.2011, p. 1509-1517.

Research output: Contribution to journalArticle

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