The energetics of intramolecular reactions and enzyme catalysis.

M. I. Page

Research output: Contribution to journalReview articlepeer-review

35 Citations (Scopus)


The relative rates of reactions should always be examined by an awareness of differential effects. The magnitude and variation of the relative rates of intramolecular reactions can be rationalized by the differences in entropy and strain energy. The relative rates of enzyme-catalysed reactions are sometimes due to groundstate effects. The beta-lactamase-catalysed hydrolysis of beta-lactam antibiotics may require a unique disposition of catalytic groups owing to an unusual process of bond fission in the four membered ring.

Original languageEnglish
Pages (from-to)149-156
Number of pages8
JournalPhilosophical transactions of the Royal Society of London. Series B, Biological sciences
Issue number1263
Publication statusPublished - 29 May 1991


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