Abstract
The relative rates of reactions should always be examined by an awareness of differential effects. The magnitude and variation of the relative rates of intramolecular reactions can be rationalized by the differences in entropy and strain energy. The relative rates of enzyme-catalysed reactions are sometimes due to groundstate effects. The beta-lactamase-catalysed hydrolysis of beta-lactam antibiotics may require a unique disposition of catalytic groups owing to an unusual process of bond fission in the four membered ring.
| Original language | English |
|---|---|
| Pages (from-to) | 149-156 |
| Number of pages | 8 |
| Journal | Philosophical transactions of the Royal Society of London. Series B, Biological sciences |
| Volume | 332 |
| Issue number | 1263 |
| DOIs | |
| Publication status | Published - 29 May 1991 |
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The energetics of intramolecular reactions and enzyme catalysis. / Page, M. I.
In: Philosophical transactions of the Royal Society of London. Series B, Biological sciences, Vol. 332, No. 1263, 29.05.1991, p. 149-156.Research output: Contribution to journal › Review article
TY - JOUR
T1 - The energetics of intramolecular reactions and enzyme catalysis.
AU - Page, M. I.
PY - 1991/5/29
Y1 - 1991/5/29
N2 - The relative rates of reactions should always be examined by an awareness of differential effects. The magnitude and variation of the relative rates of intramolecular reactions can be rationalized by the differences in entropy and strain energy. The relative rates of enzyme-catalysed reactions are sometimes due to groundstate effects. The beta-lactamase-catalysed hydrolysis of beta-lactam antibiotics may require a unique disposition of catalytic groups owing to an unusual process of bond fission in the four membered ring.
AB - The relative rates of reactions should always be examined by an awareness of differential effects. The magnitude and variation of the relative rates of intramolecular reactions can be rationalized by the differences in entropy and strain energy. The relative rates of enzyme-catalysed reactions are sometimes due to groundstate effects. The beta-lactamase-catalysed hydrolysis of beta-lactam antibiotics may require a unique disposition of catalytic groups owing to an unusual process of bond fission in the four membered ring.
UR - http://www.scopus.com/inward/record.url?scp=0026433541&partnerID=8YFLogxK
U2 - 10.1098/rstb.1991.0043
DO - 10.1098/rstb.1991.0043
M3 - Review article
C2 - 1678533
AN - SCOPUS:0026433541
VL - 332
SP - 149
EP - 156
JO - Philosophical Transactions of the Royal Society B: Biological Sciences
JF - Philosophical Transactions of the Royal Society B: Biological Sciences
SN - 0800-4622
IS - 1263
ER -