The energetics of intramolecular reactions and enzyme catalysis.

M. I. Page

doi:10.1098/rstb.1991.0043

The energetics of intramolecular reactions and enzyme catalysis.

M. I. Page

Research output: Contribution to journal › Review article › peer-review

34 Citations (Scopus)

Abstract

The relative rates of reactions should always be examined by an awareness of differential effects. The magnitude and variation of the relative rates of intramolecular reactions can be rationalized by the differences in entropy and strain energy. The relative rates of enzyme-catalysed reactions are sometimes due to groundstate effects. The beta-lactamase-catalysed hydrolysis of beta-lactam antibiotics may require a unique disposition of catalytic groups owing to an unusual process of bond fission in the four membered ring.

Original language	English
Pages (from-to)	149-156
Number of pages	8
Journal	Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Volume	332
Issue number	1263
DOIs	https://doi.org/10.1098/rstb.1991.0043
Publication status	Published - 29 May 1991

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