The Esterase Catalysed Resolution of Lactones and Spirodilactone

Patrick Barton, Michael I. Page

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


The pig liver esterase catalysed hydrolysis of spirodilactone and γ-phenyl-γ-butyrolactone gives optically active products (>90% e.e., after 50% reaction). However, the similarly substituted acyclic ester analogues of the lactone do not exhibit enantioselectivity suggesting that the acylation step shows the selectivity. Racemic spirodilactone can be converted, in principle, entirely into one of its enantiomers.

Original languageEnglish
Pages (from-to)2317-2318
Number of pages2
JournalJournal of the Chemical Society, Perkin Transactions 2
Issue number12
Publication statusPublished - Dec 1993


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