The Esterase Catalysed Resolution of Lactones and Spirodilactone

Patrick Barton, Michael I. Page

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The pig liver esterase catalysed hydrolysis of spirodilactone and γ-phenyl-γ-butyrolactone gives optically active products (>90% e.e., after 50% reaction). However, the similarly substituted acyclic ester analogues of the lactone do not exhibit enantioselectivity suggesting that the acylation step shows the selectivity. Racemic spirodilactone can be converted, in principle, entirely into one of its enantiomers.

LanguageEnglish
Pages2317-2318
Number of pages2
JournalJournal of the Chemical Society, Perkin Transactions 2
Issue number12
DOIs
Publication statusPublished - Dec 1993

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4-Butyrolactone
Acylation
Enantiomers
Enantioselectivity
Lactones
Esterases
Liver
Hydrolysis
Esters

Cite this

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The Esterase Catalysed Resolution of Lactones and Spirodilactone. / Barton, Patrick; Page, Michael I.

In: Journal of the Chemical Society, Perkin Transactions 2, No. 12, 12.1993, p. 2317-2318.

Research output: Contribution to journalArticle

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