TY - JOUR
T1 - The Esterase Catalysed Resolution of Lactones and Spirodilactone
AU - Barton, Patrick
AU - Page, Michael I.
PY - 1993/12
Y1 - 1993/12
N2 - The pig liver esterase catalysed hydrolysis of spirodilactone and γ-phenyl-γ-butyrolactone gives optically active products (>90% e.e., after 50% reaction). However, the similarly substituted acyclic ester analogues of the lactone do not exhibit enantioselectivity suggesting that the acylation step shows the selectivity. Racemic spirodilactone can be converted, in principle, entirely into one of its enantiomers.
AB - The pig liver esterase catalysed hydrolysis of spirodilactone and γ-phenyl-γ-butyrolactone gives optically active products (>90% e.e., after 50% reaction). However, the similarly substituted acyclic ester analogues of the lactone do not exhibit enantioselectivity suggesting that the acylation step shows the selectivity. Racemic spirodilactone can be converted, in principle, entirely into one of its enantiomers.
UR - http://www.scopus.com/inward/record.url?scp=37049076358&partnerID=8YFLogxK
U2 - 10.1039/P29930002317
DO - 10.1039/P29930002317
M3 - Article
AN - SCOPUS:37049076358
SP - 2317
EP - 2318
JO - Journal of the Chemical Society, Perkin Transactions 2
JF - Journal of the Chemical Society, Perkin Transactions 2
SN - 0300-922X
IS - 12
ER -