The evolution of organellar metabolism in unicellular eukaryotes

Michael L. Ginger, Geoffrey I. McFadden, Paul A.M. Michels

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Metabolic innovation has facilitated the radiation of microbes into almost every niche environment on the Earth, and over geological time scales transformed the planet on which we live. A notable example of innovation is the evolution of oxygenic photosynthesis which was a prelude to the gradual transformation of an anoxic Earth into a world with oxygenated oceans and an oxygen-rich atmosphere capable of supporting complex multicellular organisms. The influence of microbial innovation on the Earth's history and the timing of pivotal events have been addressed in other recent themed editions of Philosophical Transactions of Royal Society B (Cavalier-Smith et al. 2006; Bendall et al. 2008). In this issue, our contributors provide a timely history of metabolic innovation and adaptation within unicellular eukaryotes. In eukaryotes, diverse metabolic portfolios are compartmentalized across multiple membrane-bounded compartments (or organelles). However, as a consequence of pathway retargeting, organelle degeneration or novel endosymbiotic associations, the metabolic repertoires of protists often differ extensively from classic textbook descriptions of intermediary metabolism. These differences are often important in the context of niche adaptation or the structure of microbial communities. Fundamentally interesting in its own right, the biochemical, cell biological and phylogenomic investigation of organellar metabolism also has wider relevance. For instance, in some pathogens, notably those causing some of the most significant tropical diseases, including malaria, unusual organellar metabolism provides important new drug targets. Moreover, the study of organellar metabolism in protists continues to provide critical insight into our understanding of eukaryotic evolution.

LanguageEnglish
Pages693-698
Number of pages6
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume365
Issue number1541
Early online date2 Feb 2010
DOIs
Publication statusPublished - 12 Mar 2010
Externally publishedYes

Fingerprint

Eukaryota
Metabolism
eukaryotic cells
Innovation
metabolism
Earth (planet)
Organelles
organelles
niches
Planets
Textbooks
Photosynthesis
new drugs
Pathogens
Atmosphere
Oceans and Seas
malaria
Malaria
microbial communities
oceans

Cite this

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The evolution of organellar metabolism in unicellular eukaryotes. / Ginger, Michael L.; McFadden, Geoffrey I.; Michels, Paul A.M.

In: Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 365, No. 1541, 12.03.2010, p. 693-698.

Research output: Contribution to journalReview article

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