The Genetic Basis of Dupuytren’s Disease

An Introduction

Guido H. Dolmans, Hans Hennies

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Dupuytren’s disease is a multifactorial disorder. Twin studies and familial studies have demonstrated a strong genetic component for Dupuytren’s disease. An autosomal dominant mode of inheritance with reduced penetrance has been suggested; however, a gene involved in Dupuytren’s disease using a family-based gene mapping approach has not been identified so far. Therefore we have embarked on a genome-wide association study to identify susceptibility genes for Dupuytren’s disease. Here we give a brief introduction into molecular studies of multifactorial disorders and describe basic approaches used in these studies. Based on recent findings concerning the genetics of Dupuytren’s disease, we explain the rationale for our approach and the conclusions that could be expected from the work. Additionally, this chapter may serve as a brief introduction into the genetic studies in Dupuytren’s disease.
Original languageEnglish
Title of host publicationDupuytren’s Disease and Related Hyperproliferative Disorders
Subtitle of host publicationPrinciples, Research, and Clinical Perspectives
EditorsCharles Eaton, M. Heinrich Seegenschmiedt, Ardeshir Bayat, Giulio Gabbiani, Paul Werker, Wolfgang Wach
PublisherSpringer Verlag
Pages87-93
Number of pages5
ISBN (Electronic)9783642226977
ISBN (Print)9783642226960
DOIs
Publication statusPublished - 2012
Externally publishedYes

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Dupuytren Contracture
Inborn Genetic Diseases
Twin Studies
Penetrance
Chromosome Mapping
Genome-Wide Association Study
Genes

Cite this

Dolmans, G. H., & Hennies, H. (2012). The Genetic Basis of Dupuytren’s Disease: An Introduction. In C. Eaton, M. H. Seegenschmiedt, A. Bayat, G. Gabbiani, P. Werker, & W. Wach (Eds.), Dupuytren’s Disease and Related Hyperproliferative Disorders: Principles, Research, and Clinical Perspectives (pp. 87-93). Springer Verlag. https://doi.org/10.1007/978-3-642-22697-7_11
Dolmans, Guido H. ; Hennies, Hans. / The Genetic Basis of Dupuytren’s Disease : An Introduction. Dupuytren’s Disease and Related Hyperproliferative Disorders: Principles, Research, and Clinical Perspectives. editor / Charles Eaton ; M. Heinrich Seegenschmiedt ; Ardeshir Bayat ; Giulio Gabbiani ; Paul Werker ; Wolfgang Wach. Springer Verlag, 2012. pp. 87-93
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Dolmans, GH & Hennies, H 2012, The Genetic Basis of Dupuytren’s Disease: An Introduction. in C Eaton, MH Seegenschmiedt, A Bayat, G Gabbiani, P Werker & W Wach (eds), Dupuytren’s Disease and Related Hyperproliferative Disorders: Principles, Research, and Clinical Perspectives. Springer Verlag, pp. 87-93. https://doi.org/10.1007/978-3-642-22697-7_11

The Genetic Basis of Dupuytren’s Disease : An Introduction. / Dolmans, Guido H.; Hennies, Hans.

Dupuytren’s Disease and Related Hyperproliferative Disorders: Principles, Research, and Clinical Perspectives. ed. / Charles Eaton; M. Heinrich Seegenschmiedt; Ardeshir Bayat; Giulio Gabbiani; Paul Werker; Wolfgang Wach. Springer Verlag, 2012. p. 87-93.

Research output: Chapter in Book/Report/Conference proceedingChapter

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AB - Dupuytren’s disease is a multifactorial disorder. Twin studies and familial studies have demonstrated a strong genetic component for Dupuytren’s disease. An autosomal dominant mode of inheritance with reduced penetrance has been suggested; however, a gene involved in Dupuytren’s disease using a family-based gene mapping approach has not been identified so far. Therefore we have embarked on a genome-wide association study to identify susceptibility genes for Dupuytren’s disease. Here we give a brief introduction into molecular studies of multifactorial disorders and describe basic approaches used in these studies. Based on recent findings concerning the genetics of Dupuytren’s disease, we explain the rationale for our approach and the conclusions that could be expected from the work. Additionally, this chapter may serve as a brief introduction into the genetic studies in Dupuytren’s disease.

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KW - Incidence

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BT - Dupuytren’s Disease and Related Hyperproliferative Disorders

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Dolmans GH, Hennies H. The Genetic Basis of Dupuytren’s Disease: An Introduction. In Eaton C, Seegenschmiedt MH, Bayat A, Gabbiani G, Werker P, Wach W, editors, Dupuytren’s Disease and Related Hyperproliferative Disorders: Principles, Research, and Clinical Perspectives. Springer Verlag. 2012. p. 87-93 https://doi.org/10.1007/978-3-642-22697-7_11